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职业迁徙
个人简介
HONORS:
Award of Distinguished Thesis, Tien-Te Lee Biomedical Foundation, Taiwan (2008)
Ta-Yu Wu Memorial Award, National Science Council, Taiwan (2008)
Dr. Ta-Cheng Tung Memorial Award for Basic Cancer Research, Chinese Oncology Society, Taiwan (2009)
First prize of Distinguished Thesis, Taipei Veterans General Hospital (2009, 2011)
Young Scientist Research Award, Tien-Te Lee Biomedical Foundation, Taiwan (2011)
Award for Junior Research Investigators, Academia Sinica (2011)
RESEARCH INTERESTS:
Epithelial-mesenchymal transition (EMT) is one of the major mechanisms of cancer metastasis. However, the pleiotropic effects of EMT regulators in additional to the promotion of cellular migration have been investigated limitedly. We recently discover several novel functions of the EMT regulators during head and neck cancer progression. First, we confirm the direct regulation of the stemness-related gene BMI1 by the EMT regulator Twist1. Twist1 and BMI1 are mutually essential in promoting EMT and tumor-initiating capability. Second, we identify the mechanism of Twist1-induced motility through repressing microRNA let-7i and activating RAC1. Third, we show the induction of chromosomal instability by BMI1 through upregulating Aurora A expression. Fourth, we find a pathway of Snail-induced cisplatin resistance through induction of ERCC1 expression. In the future, we will keep focusing on the pleiotropic effects of EMT regulators during cancer metastasis and confirm their clinical significance.
Award of Distinguished Thesis, Tien-Te Lee Biomedical Foundation, Taiwan (2008)
Ta-Yu Wu Memorial Award, National Science Council, Taiwan (2008)
Dr. Ta-Cheng Tung Memorial Award for Basic Cancer Research, Chinese Oncology Society, Taiwan (2009)
First prize of Distinguished Thesis, Taipei Veterans General Hospital (2009, 2011)
Young Scientist Research Award, Tien-Te Lee Biomedical Foundation, Taiwan (2011)
Award for Junior Research Investigators, Academia Sinica (2011)
RESEARCH INTERESTS:
Epithelial-mesenchymal transition (EMT) is one of the major mechanisms of cancer metastasis. However, the pleiotropic effects of EMT regulators in additional to the promotion of cellular migration have been investigated limitedly. We recently discover several novel functions of the EMT regulators during head and neck cancer progression. First, we confirm the direct regulation of the stemness-related gene BMI1 by the EMT regulator Twist1. Twist1 and BMI1 are mutually essential in promoting EMT and tumor-initiating capability. Second, we identify the mechanism of Twist1-induced motility through repressing microRNA let-7i and activating RAC1. Third, we show the induction of chromosomal instability by BMI1 through upregulating Aurora A expression. Fourth, we find a pathway of Snail-induced cisplatin resistance through induction of ERCC1 expression. In the future, we will keep focusing on the pleiotropic effects of EMT regulators during cancer metastasis and confirm their clinical significance.
研究兴趣
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