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The generation and differentiation of neurons and glial cells are dependent upon cell-cell interactions mediated by a wide variety of growth factors and cytokines. The laboratory is interested in receptor-mediated mechanisms that direct cell differentiation versus cell proliferation in the nervous system. A major goal is to identify the biochemical steps that provide specificity in NGF signaling. Control of cell survival and death by neurotrophins is dictated by an unusual transduction system consisting of two transmembrane receptors, the TrkA tyrosine kinase and the p75 neurotrophin receptor, a member of the TNF receptor superfamily. Members of the NGF family are responsible for neuronal cell survival by activating Trk tyrosine kinases. However, NGF can have the opposite effect, promoting a cell death signal through the p75 receptor. NGF can induce apoptosis of mature oligodendrocytes cultured from rat cerebral cortex. NGF binding to oligodendrocytes expressing the p75 receptor, but not TrkA, resulted in an increase c-jun kinase and caspase activity. Therefore, NGF has the ability of promoting cell survival and cell death in specific cell types through novel signaling mechanisms involving TrkA and p75 receptors. The structural and biochemical features of these two receptors are being defined together with their intracellular signaling mechanisms.
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Philip Hasel, Melissa Cooper, Anne E Marchildon, Uriel Rufen-Blanchette,Rachel D Kim,Thong Ma,Un Jung Kang,Moses V. Chao,Shane A. Liddelow
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Pernille B Thomassen,Alena Salasova,Hande Login, S Beel, Jeppe Tranberg-Jensen,Per Qvist, Peter Lund Ovesen, Stella Nolte,LN Nejsum,Moses V Chao,J Dasen,P Van Damme,
biorxiv(2023)
iScienceno. 4 (2023): 106545-106545
Pernille Bogetofte Thomasen,Alena Salasova,Kasper Kjaer-Sorensen,Lucie Woloszczuková,Josef Lavický,Hande Login, Jeppe Tranberg-Jensen,Sergio Almeida,Sander Beel, Michaela Kavková,Per Qvist,Mads Kjolby,
Hui-Lan Hu, Latika Khatri,Marilyn Santacruz, Emily Church,Christopher Moore,Tony T. Huang,Moses Victor Chao
SSRN Electronic Journal (2022): 1179209-1179209
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