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Buchsbaum is a pioneer in the use of neuroimaging technology to study psychiatric disorders. In the early 1980s he, along with David Ingvar, performed the first positron emission tomography (PET) studies of patients with schizophrenia at the National Institutes of Health (NIH) and the patients had reduced glucose metabolism in the frontal lobe, a pattern known as hypofrontality. His research has led to him being called as an expert witness during criminal trials.
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