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个人简介
Dr Shamji has a specific interest in respiratory allergies, especially how disease-modifying treatments such as allergen immunotherapy, novel biologics and novel immunomodulators (Toll-Like Receptor (TLR) 7 and Surfactant protein (SP)-D) affect immunologic (T, B cell and immunoglobulins) responses leading to induction of immune tolerance, as well as the investigation of novel surrogate/predictive biomarkers of clinical outcome following successful immunotherapy.
He is actively involved in evaluating novel approaches of allergen immunotherapy using modified hypoallergic form of allergen protein, subcutaneous immunotherapy in combination with novel adjuvants, sublingual immunotherapy, peptide immunotherapy, biologics plus allergen of interest strategies to improve safety, efficacy and induce immune tolerance to sensitising allergen.
This involves:
1) Designing human pre-clinical laboratory mechanistic studies to test allergenicity and immunogenicity of novel modified/hypoallergenic allergen and T/B cell peptides
2) Investigating immunologic mechanisms of immunotherapy in the context of clinical trials (in collaboration with Professor Stephen Durham, within Allergy and Clinical Immunology (ACI) or contract research organisation (CRO), pharmaceutical or biotech companies).
In collaboration with Professor Adnan Custovic and Dr Paul Turner, Dr Shamji is investigating mechanisms of desensitisation and tolerance induction following oral peanut/milk immunotherapy by translating his work from respiratory disease human models.
Dr Shamji’s research has resulted in multiple peer-reviewed publications in high impact journals in the field of Allergy. His publications in the Journal of Allergy and Clinical Immunology have been selected as editor’s choice. He has written two book chapters on mechanisms and biomarkers of AIT (Allergens and Allergen Immunotherapy: Subcutaneous, Sublingual, and Oral, Fifth Edition, CRC press).
He is actively involved in evaluating novel approaches of allergen immunotherapy using modified hypoallergic form of allergen protein, subcutaneous immunotherapy in combination with novel adjuvants, sublingual immunotherapy, peptide immunotherapy, biologics plus allergen of interest strategies to improve safety, efficacy and induce immune tolerance to sensitising allergen.
This involves:
1) Designing human pre-clinical laboratory mechanistic studies to test allergenicity and immunogenicity of novel modified/hypoallergenic allergen and T/B cell peptides
2) Investigating immunologic mechanisms of immunotherapy in the context of clinical trials (in collaboration with Professor Stephen Durham, within Allergy and Clinical Immunology (ACI) or contract research organisation (CRO), pharmaceutical or biotech companies).
In collaboration with Professor Adnan Custovic and Dr Paul Turner, Dr Shamji is investigating mechanisms of desensitisation and tolerance induction following oral peanut/milk immunotherapy by translating his work from respiratory disease human models.
Dr Shamji’s research has resulted in multiple peer-reviewed publications in high impact journals in the field of Allergy. His publications in the Journal of Allergy and Clinical Immunology have been selected as editor’s choice. He has written two book chapters on mechanisms and biomarkers of AIT (Allergens and Allergen Immunotherapy: Subcutaneous, Sublingual, and Oral, Fifth Edition, CRC press).
研究兴趣
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Sviatlana Starchenka,Kemi Oluwayi,Matthew Heath,Oliver Armfield,Mohamed Shamji,Janice Layhadi, Katarzyna Lis, Lisa Cadavez,Olesya Rusyn,Murray Skinner,Pieter-Jan De Kam
CLINICAL AND EXPERIMENTAL ALLERGYno. 2 (2024): 130-142
Andreina Marques-Mejias,Irene Bartha, Christina E. Ciaccio,R. Sharon Chinthrajah,Susan Chan,Gurjit K. Khurana Hershey, Jessica W. Hui-Beckman,Laurie Kost,Gideon Lack,Janice A. Layhadi,Donald Y.M. Leung,Hannah F. Marshall,
Annals of Allergy, Asthma & Immunology (2024)
Ibon Eguiluz-Gracia,Rebecca V. Parkin,Janice A. Layhadi,Elizabeth Palmer, Xun Meng, Rongfei Zhu, Umit Sahiner, Stephen R. Durham,Maria Jose Torres,Cristobalina Mayorga,Carmen Rondon,Mohamed H. Shamji
ALLERGY (2024)
Janice A. Layhadi, Anastasia Lalioti,Elizabeth Palmer,Menno C. van Zelm,Erik Wambre,Mohamed H. Shamji
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICEno. 1 (2024): 59-66
M. Pascal, S. M. Edelman,A. Nopp, C. Moebs, W. J. Geilenkeuser,E. F. Knol,D. G. Ebo,C. Mertens,M. H. Shamji,A. F. Santos,S. Patil,B. Eberlein,
ALLERGYno. 2 (2024): 290-293
Stefanie Busold,Lorenz Aglas,Charlotte Menage,Rejean Desgagnes,Loic Faye, Anne-Catherine Fitchette,Esther C. de Jong,Caroline Martel,Maria Stigler, Virginie Catala-Stordeur,Guy Tropper,Lydia Auger,
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2024)
Pieter-Jan de Kam,Stefan Zielen, Jonathan Bernstein, Uwe E. Berger MBA, Markus Berger, M. Cuevas, D. Cypcar, A. Fuhr-Horst, W.A. Greisner, M. Jandl, Sabine Lassmann,Margitta Worm,
crossref(2024)
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunologyno. 4 (2024): 238-240
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