Minh Le
助理教授
Department of Pharmacology
Yong Loo Lin School of Medicine, National University of Singapore;Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore;Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore
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个人简介
Dr. Le is well recognized for her contributions to the field of microRNAs (miRNAs), extracellular vesicles (EVs) and cancer biology. She was the first to identify a miRNA that regulates p53, an important tumor suppressor gene. This miRNA, miR-125b, was subsequently found to be a potent oncogenic miRNA in leukemia and many solid tumors. Dr. Le characterized the anti-apoptotic functions of miR-125b in zebrafish embryos and mammalian cells. She demonstrated that this tiny RNA is dispensable for normal development as it regulates the delicate balance between cell death and growth by repressing the p53 gene network. Furthermore, during her postdoctoral training, Dr. Le illustrated a novel mechanism of cancer crosstalk in which miRNAs secreted by metastatic breast cancer cells are delivered to non-metastatic cells via extracellular vesicles (EVs) and promote colonization of tumor cells in the lung. Recently, our group has established a new EV-based drug delivery platform with efficient and safe delivery of RNA drugs to cancer cells. With these original findings, Dr. Le’s articles have been cited over 2,000 times by researchers worldwide.
研究兴趣
论文共 67 篇作者统计合作学者相似作者
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Brenda Wan Shing Lam,Ping Xiang,Boya Peng, Ling Jun Joshua Soon, Amelia Ting Yu Yam, Claudine Ming Hui Lim, Yu Zheng,Long N. Nguyen, Deron R. Herr,Minh T. N. Le
Xuan T. T. Dang, Cao Dai Phung, Claudine Ming Hui Lim,Migara Kavishka Jayasinghe, Jorgen Ang, Thai Tran,Herbert Schwarz,Minh T. N. Le
Migara Kavishka Jayasinghe, Dawn Liu Xiao Tian, Yock Sin Lay,Chang Yu Lee, Brendon Zhi Jie Yeo, Dong Van Hoang, Rebecca Carissa Prajogo,Boya Peng,Thach Tuan Pham,Minh Thi Nguyet Le
Kiyofumi Hamashima, Ka Wai Wong, Tsz Wing Sam, Jia Hao Jackie Teo,Reshma Taneja,Minh T.N. Le, Qi-Jing Li,Jacob H. Hanna,Hu Li,Yuin-Han Loh
Molecular cellno. 17 (2023): 3205-3216.e5
ACS nanono. 6 (2023): 5187-5210
Migara K. Jayasinghe,Chang Gao,Gracemary Yap, Brendon Zhi Jie Yeo,Luyen Tien Vu,Douglas Jie Wen Tay, Wen Xiu Loh,Zhen Qin Aw,Huixin Chen,Dai Cao Phung, Dong Van Hoang, Rebecca Carissa Prajogo,
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