基本信息
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个人简介
Primary fields of research
Micro/nanoparticulate systems may provide bio-actives with a few functionalities, e.g. targeted delivery, extended effects, improved stability, enhanced solubility, enhanced bioavailability and reduced side effects, which are desired for various medical uses such as drug delivery, tissue engineering and new therapies. Mechanistic understanding of the formation process of the micro/nanoparticles and their impact on bio-environment is essential for rational design of these systems. My research interests include understanding physical and chemical mechanisms that determine the engineering of aforementioned micro/nanoparticulate systems with optimal functionalities, the interplay between the micro/nanoparticulates and bio-membranes or cells, as well as the mechanisms that control the release of the bio-actives from the micro/nanoparticulate systems.
Current research
The current research is focused on engineering of micro/nanoparticles or nano-composite particles via wet chemistry or atomization technologies including spray-drying, spray freeze-drying and electrospraying/electrospinning for respiratory, peroral or subcutaneous administration of poorly water-soluble drugs, protein/peptide drugs and siRNA. Another emphasis of the current research is placed on characterization of the physical and chemical stability of the protein and peptide drugs upon the processing.
Micro/nanoparticulate systems may provide bio-actives with a few functionalities, e.g. targeted delivery, extended effects, improved stability, enhanced solubility, enhanced bioavailability and reduced side effects, which are desired for various medical uses such as drug delivery, tissue engineering and new therapies. Mechanistic understanding of the formation process of the micro/nanoparticles and their impact on bio-environment is essential for rational design of these systems. My research interests include understanding physical and chemical mechanisms that determine the engineering of aforementioned micro/nanoparticulate systems with optimal functionalities, the interplay between the micro/nanoparticulates and bio-membranes or cells, as well as the mechanisms that control the release of the bio-actives from the micro/nanoparticulate systems.
Current research
The current research is focused on engineering of micro/nanoparticles or nano-composite particles via wet chemistry or atomization technologies including spray-drying, spray freeze-drying and electrospraying/electrospinning for respiratory, peroral or subcutaneous administration of poorly water-soluble drugs, protein/peptide drugs and siRNA. Another emphasis of the current research is placed on characterization of the physical and chemical stability of the protein and peptide drugs upon the processing.
研究兴趣
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