基本信息
浏览量:2
职业迁徙
个人简介
My prior studies focused on the pathogenesis of cigarette-smoke (CS) -induced lung diseases such as chronic obstructive pulmonary disease (COPD), wherein we demonstrated that the IL-18 system plays an important role in the pathogenesis of CS-induced emphysematous lung destruction. These studies led me to question the effect of CS on innate immunity on the interaction between the host and microorganisms and, for this purpose, I had established a murine cigarette smoke and virus co-exposure model. These studies revealed important insight into the interaction between CS and the innate immunity resulting in a publication in the Journal of Clinical Investigation. In that study, we identified that CS smoke selectively augments respiratory antiviral innate immune responses via a MAVS-RLHs antiviral signaling pathway. To gain better understanding of the mechanisms, my laboratory is focusing on the role(s) of mitochondrial dysfunction and immune dysregulation in the setting of smoking exposure. By applying recent state-of-art knowledge of mitochondrial biology, our research goal is to establish mitochondrial dysfunction and mitochondrial injury/damage responses as a key event in the pathogenesis of COPD and CS-and virus-associated disorders and as such, to provide a new perspective of our understanding of COPD and CS-and virus-associated disorders.
研究兴趣
论文共 63 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Jae Yeol Kim,Jae-Woo Jung,Min-Jong Kang,Deog Kyeom Kim,Hayoung Choi,Young-Jae Cho,Seung Hun Jang,Chang-Hoon Lee, Yeon Mok Oh, Ji Sook Park
引用0浏览0WOS引用
0
0
The Korean Journal of Internal Medicineno. 5 (2023): 714-724
引用0浏览0引用
0
0
Journal of immunology (Baltimore, Md. : 1950)no. 7 (2022): 1314-1322
American Journal of Respiratory Cell and Molecular Biologyno. 1 (2022): 22-33
引用2浏览0WOS引用
2
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn