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个人简介
Egeblad is an internationally recognized cancer researcher who studies how the tumor microenvironment—the immune cells, blood vessels, chemical signals, and support matrix surrounding a tumor—regulates cancer initiation, progression, and metastasis. Egeblad’s ultimate goal is to help cancer patients mitigate their risk of recurrence and metastasis, and her work holds promise for potential future treatment options.
While most microenvironments help tumors grow and metastasize, some can restrict tumors. Egeblad investigates how to target the bad microenvironments and support the good ones to prevent metastatic spread. She examines the functions of immune cells known as myeloid cells, how different types of myeloid cells are recruited to tumors, and how signals between the myeloid cells and cancer cells or other immune cells influence cancer progression, including metastasis, as well as response to chemotherapy. Egeblad has been a driving force in identifying the mechanisms by which neutrophils—a specific type of myeloid cell—influence cancer progression, and specifically how neutrophil extracellular traps can promote cancer recurrence and metastasis. A current line of research involves learning more about how the brain regulates the immune system to combat cancer.
While most microenvironments help tumors grow and metastasize, some can restrict tumors. Egeblad investigates how to target the bad microenvironments and support the good ones to prevent metastatic spread. She examines the functions of immune cells known as myeloid cells, how different types of myeloid cells are recruited to tumors, and how signals between the myeloid cells and cancer cells or other immune cells influence cancer progression, including metastasis, as well as response to chemotherapy. Egeblad has been a driving force in identifying the mechanisms by which neutrophils—a specific type of myeloid cell—influence cancer progression, and specifically how neutrophil extracellular traps can promote cancer recurrence and metastasis. A current line of research involves learning more about how the brain regulates the immune system to combat cancer.
研究兴趣
论文共 150 篇作者统计合作学者相似作者
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Daniel Hirschhorn,Lukas Kraehenbuehl,Sadna Budhu, Valeria Estrada Navarro,Levi Mark B Mangarin, Yacine Marouf,Jacob Ricca,Billel Gasmi,Olivier De Henau,Yanyun Li,Czrina Cortez,Hamadene Linda,
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Cancer cellno. 3 (2024): 474-486.e12
Ana Paula Delgado,Alice Nemajerova, Brian J Nelson,Manisha Rao,Jinyu Li,Natalia Marchenko,Jonathan Preall,Ute M Moll,Mikala Egeblad,Scott Powers
biorxiv(2024)
Emma Gazzara,Jose Adrover, Alex Liu, Song Han, Arvind Rishi, Charlie Chung, Craig Devoe,Hai Huang, Danielle DePeralta, Matthew Weiss, Semir Beyaz, Peter Westcott,
ANNALS OF SURGICAL ONCOLOGYno. 1 (2024): S54-S54
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Xue-Yan He, Yuan Gao,David Ng, Evdokia Michalopoulou, Shanu George,Jose M. Adrover,Lijuan Sun,Jean Albrengues,Juliane Daßler-Plenker,Xiao Han, Ledong Wan,Xiaoli S. Wu,
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Natureno. 7964 (2023): 374-382
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CANCER RESEARCHno. 7 (2023)
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Alexandra Mousset, Enora Lecorgne,Isabelle Bourget,Pascal Lopez, Kitti Jenovai,Julien Cherfils-Vicini,Chloé Dominici,Géraldine Rios, Cédric Girard-Riboulleau,Bodu Liu,David L Spector,Sidse Ehmsen,
David Ng, Katherine S Panageas,Jedd D Wolchok,Taha Merghoub,Sadna Budhu,Olivier De Henau,Yanyun Li,Billel Gasmi, Cailian Liu,Sara Schad,Rebekka Duhen,Andrew D Weinberg,
Journal for ImmunoTherapy of Cancerno. Suppl 1 (2023)
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