My research interests lie principally, but not exclusively, in the field of reproductive and perinatal epidemiology. I have spent the last two decades focused on integrating epidemiological, biological and molecular approaches into rigorously designed clinical epidemiology research projects that have led to greater understandings of the etiology and pathophysiology of placental abruption, gestational diabetes, and preeclampsia. My research programs were developed through (1) identifying gaps in the literature; (2) constructing methodologically rigorous, versatile and robust epidemiological data capture systems and networks (epidemiology platforms) in North America, Sub-Saharan Africa, Asia, and South America; and (3) proactively and strategically integrating biochemical and molecular biomarkers onto that epidemiology platform. I have fully exploited the arsenal of epidemiology study designs (case-control, self-matched case-crossover, and prospective cohort studies) to answer important questions concerning the etiology and pathophysiology of a relatively broad spectrum of adverse reproductive and perinatal outcomes.