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职业迁徙
个人简介
My group's research focuses on engineering metal binding sites into peptides or proteins, through incorporation of a synthetic chelating group or selection of amino acids with affinity for a specific transition metal. I am particularly interested in synthesising and testing new bifunctional chelators that firstly, allow for simple attachment of the chelator to biomolecules such as peptides, proteins, nanoparticles and other targeting vectors, and secondly, allow for coordination of radioactive metal isotopes (including 68Ga, 99mTc, 64Cu, 213Bi, 89Zr, 52Mn and 188Re) that are used in diagnostic imaging or radiotherapy.
These chelator platforms provide versatile tools for nuclear medicine applications, including tracking the migration of cells in vivo, whole body imaging of disease with PET and SPECT, evaluating new protein-based therapies, and targetting radiotherapy of tumours.
These chelator platforms provide versatile tools for nuclear medicine applications, including tracking the migration of cells in vivo, whole body imaging of disease with PET and SPECT, evaluating new protein-based therapies, and targetting radiotherapy of tumours.
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Bioconjugate chemistryno. 10 (2023): 1802-1810
Cormac A. A. Kelderman, Rachel C. Maclean,Ingebjorg N. Hungnes,Patrick R. W. J. Davey,Ekaterina Salimova,Michael de Veer, Natasha Patel,Michelle T. Ma,Brett M. Paterson
INORGANIC CHEMISTRYno. 50 (2023): 20791-20805
Ingebjorg N. Hungnes,Truc Thuy Pham,Charlotte Rivas, James A. Jarvis, Rachel E. Nuttall, Saul M. Cooper,Jennifer D. Young,Philip J. Blower,Paul G. Pringle,Michelle T. Ma
INORGANIC CHEMISTRYno. 50 (2023): 20608-20620
Nuclear Medicine and Biology (2023): 108717
NUCLEAR MEDICINE AND BIOLOGY (2023): S241-S242
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Johanna Prueller,Truc Pham, Julia Blower, Putthiporn Charoenphun,Alessia Volpe,Kavitha Sunassee,Gregory Mullen,Richard Smith,Philip J Blower,Michelle Ma
Chemical communications (Cambridge, England)no. 16 (2023): 2323-2326
NUCLEAR MEDICINE AND BIOLOGY (2023): S236-S237
NUCLEAR MEDICINE AND BIOLOGY (2023): S162-S162
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