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个人简介
The O'Malley Lab works at the interface of engineering and biology to engineer microbes and consortia with novel functions. We are especially interested in deciphering how “unwieldy” microbes in the environment perform extraordinary tasks - many of these microbes have no available genomic sequence and are exceptionally difficult to manipulate. We seek a better understanding of how proteins are synthesized by cells, and how their three-dimensional structure informs their function would enhance our ability to engineer proteins (and cellular expression platforms) for diverse biomedical and biotechnology applications. To address these issues, our approach combines classical cell biology tools with cutting-edge technologies (genome sequencing, RNAseq, cellular reprogramming) that are rooted in the core biological sciences to interrogate and engineer molecular mechanisms that underlie protein production in eukaryotic cells. In addition, we rely on biophysical methods to elucidate protein-protein contacts, with the aim of controlling these interactions both in vivo and in vitro. Systems of interest to us have broad applicability to bioenergy and sustainability, as well as to drug development and detection.
Areas of interest:
Genetic and cellular engineering of anaerobic gut fungi
Synthetic anaerobic consortia for bioproduction and model development
Engineering synthetic fungal cellulosomes and novel biocatalysts
Membrane proteins for drug discovery, detection, and diagnostics
New membrane proteins for synthetic biology
研究兴趣
论文共 127 篇作者统计合作学者相似作者
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Hugo Doré, Amy R Eisenberg, Emily N Junkins,Gabriel E Leventhal, Anakha Ganesh,Otto X Cordero,Blair G Paul,David L Valentine,Michelle A O'Malley,Elizabeth G Wilbanks
Proceedings of the National Academy of Sciences of the United States of Americano. 9 (2024): e2316469121-e2316469121
Na Liu,Veronika Kivenson,Xuefeng Peng,Zhisong Cui, Thomas S. Lankiewicz,Kelsey M. Gosselin, Chance J. English, Elaina M. Blair,Michelle A. O'Malley,David L. Valentine
APPLIED AND ENVIRONMENTAL MICROBIOLOGYno. 2 (2024): e0091423-e0091423
Frontiers in fungal biology (2023): 1171100-1171100
Protein science : a publication of the Protein Societyno. 9 (2023)
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Chung-Ta Han,Khanh Dinh Quoc Nguyen,Maxwell W Berkow,Sunyia Hussain, Ahmad Kiani,Maia Kinnebrew,Matthew N Idso,Naomi Baxter,Evelyn Chang,Emily Aye, Elsa Winslow,Mohammad Rahman,
Protein expression and purification (2023): 106323
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