Michael T. Rudd

Dept Discovery Chem Merck & Co Inc

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论文共 27 篇作者统计合作学者相似作者

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Discovery of MK-8768, a Potent and Selective Mglur2 Negative Allosteric Modulator

Michael T. Rudd,Peter J. Manley,Barbara Hanney,Zhaoyang Meng,Youheng Shu,Pablo de Leon, Jessica L. Frie,Yongxin Han,Jenny Miu-Chun Wai,Zhi-Qiang Yang,James J. Perkins,Danielle M. Hurzy,Jesse J. Manikowski,Hong Zhu,Christopher J. Bungard,Antonella Converso,Robert S. Meissner,Mali L. Cosden, Ikuo Hayashi,Lei Ma,Julie O'Brien,Victor N. Uebele,Joel B. Schachter,Neetesh Bhandari, Gwendolyn J. Ward,Kerry L. Fillgrove,Bing Lu,Yuexia Liang,David C. Dubost,Vanita Puri,Donnie M. Eddins,Joshua D. Vardigan,Robert E. Drolet,Jonathan T. Kern,Jason M. Uslaner

ACS Medicinal Chemistry Letters（2023）

引用3浏览0WOS引用

The PET Tracer [11C]MK-6884 Quantifies M4 Muscarinic Receptor in Rhesus Monkeys and Patients with Alzheimer’s Disease

Wenping Li,Yuchuan Wang,Talakad G. Lohith,Zhizhen Zeng,Ling Tong,Robert Mazzola,Kerry Riffel,Patricia Miller,Mona Purcell,Marie Holahan,Hyking Haley,Liza Gantert,David Hesk,Sumei Ren,John Morrow,Jason Uslaner,Arie Struyk,Jenny Miu-Chun Wai,Michael T. Rudd,David M. Tellers,Thomas McAvoy,Guy Bormans,Michel Koole,Koen Van Laere,Kim Serdons,Jan de Hoon,Ruben Declercq,Inge De Lepeleire,Maria B. Pascual,Paolo Zanotti-Fregonara,Meixiang Yu,Victoria Arbones,Joseph C. Masdeu,Amy Cheng,Azher Hussain,Tjerk Bueters,Matt S. Anderson,Eric D. Hostetler,Anthony S. Basile

Science translational medicine（2022）

引用11浏览0WOSSCIENCE引用

Structures of Active-State Orexin Receptor 2 Rationalize Peptide and Small-Molecule Agonist Recognition and Receptor Activation

Chuan Hong,Noel J. Byrne,Beata Zamlynny,Srivanya Tummala,Li Xiao,Jennifer M. Shipman,Andrea T. Partridge,Christina Minnick,Michael J. Breslin,Michael T. Rudd,Shawn J. Stachel,Vanessa L. Rada,Jeffrey C. Kern,Kira A. Armacost,Scott A. Hollingsworth,Julie A. O’Brien,Dawn L. Hall,Terrence P. McDonald,Corey Strickland,Alexei Brooun,Stephen M. Soisson,Kaspar Hollenstein

Nature Communications（2021）

引用72浏览0WOSNATURE引用

The Invention of Grazoprevir: An HCV NS3/4a Protease Inhibitor

John A. McCauley,Michael T. Rudd

Topics in Medicinal ChemistryHCV: The Journey from Discovery to a Curepp.355-387, (2019)

引用3浏览0引用

Structural Basis for Selectivity and Diversity in Angiotensin II Receptors

Haitao Zhang,Gye Won Han,Alexander Batyuk,Andrii Ishchenko,Kate L. White,Nilkanth Patel,Anastasiia Sadybekov,Beata Zamlynny,Michael T. Rudd,Kaspar Hollenstein,Alexandra Tolstikova,Thomas A. White,Mark S. Hunter,Uwe Weierstall,Wei Liu,Kerim Babaoglu,Eric L. Moore, Ryan D. Katz,Jennifer M. Shipman,Margarita Garcia-Calvo,Sujata Sharma,Payal Sheth,Stephen M. Soisson,Raymond C. Stevens,Vsevolod Katritch,Vadim Cherezov

Nature（2017）

引用217浏览0WOSNATURE引用

217

Hepatitis C Virus NS3/4a Protease Inhibitors

John A. McCauley,Michael T. Rudd

CURRENT OPINION IN PHARMACOLOGY（2016）

引用108浏览0WOS引用

108

Identification and in Vivo Evaluation of Liver X Receptor Β-Selective Agonists for the Potential Treatment of Alzheimer’s Disease

Shawn J. Stachel,Celina Zerbinatti,Michael T. Rudd,Mali Cosden,Sokreine Suon,Kausik K. Nanda,Keith Wessner,Jillian DiMuzio,Jill Maxwell,Zhenhua Wu,Jason M. Uslaner,Maria S. Michener, Peter Szczerba,Edward Brnardic,Vanessa Rada, Yuntae Kim,Robert Meissner,Peter Wuelfing, Yang Yuan,Jeanine Ballard,Marie Holahan,Daniel J. Klein,Jun Lu,Xavier Fradera,Gopal Parthasarathy,Victor N. Uebele,Zhongguo Chen,Yingjie Li,Jian Li,Andrew J. Cooke,D. Jonathan Bennett,Mark T. Bilodeau,John Renger

Journal of medicinal chemistry（2016）

引用41浏览0WOS引用

P2‐Quinazolinones and Bis‐Macrocycles As New Templates for Next‐Generation Hepatitis C Virus NS3/4a Protease Inhibitors: Discovery of MK‐2748 and MK‐6325

Michael T. Rudd,John W. Butcher,Kevin T. Nguyen,Charles J. McIntyre,Joseph J. Romano,Kevin F. Gilbert,Kimberly J. Bush,Nigel J. Liverton,M. Katharine Holloway,Steven Harper,Marco Ferrara,Marcello DiFilippo,Vincenzo Summa,John Swestock,Jeff Fritzen,Steven S. Carroll,Christine Burlein,Jillian M. DiMuzio,Adam Gates,Donald J. Graham,Qian Huang,Stephanie McClain,Carolyn McHale,Mark W. Stahlhut,Stuart Black,Robert Chase,Aileen Soriano,Christine M. Fandozzi,Anne Taylor,Nicole Trainor,David B. Olsen,Paul J. Coleman,Steven W. Ludmerer,John A. McCauley

ChemMedChem（2015）

引用23浏览0WOS引用

MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants (vol 56, pg 4161, 2012)

Vincenzo Summa,Steven W. Ludmerer,John A. McCauley,Christine Fandozzi,Christine Burlein,Giuliano Claudio,Paul J. Coleman,Jillian M. DiMuzio,Marco Ferrara,Marcello Di Filippo,Adam T. Gates,Donald J. Graham,Steven Harper,Daria J. Hazuda,Qian Huang,Carolyn McHale,Edith Monteagudo,Vincenzo Pucci,Michael Rowley,Michael T. Rudd,Aileen Soriano,Mark W. Stahlhut,Joseph P. Vacca,David B. Olsen,Nigel J. Liverton,Steven S. Carroll

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY（2014）

引用2浏览0引用

Novel Quinoline-Based P2-P4 Macrocyclic Derivatives As Pan-Genotypic HCV NS3/4a Protease Inhibitors

Unmesh Shah,Charles Jayne,Samuel Chackalamannil,Francisco Velazquez,Zhuyan Guo,Alexei Buevich,John A. Howe,Robert Chase,Aileen Soriano,Sony Agrawal,Michael T. Rudd,John A. McCauley,Nigel J. Liverton,Joseph Romano,Kimberly Bush,Paul J. Coleman,Christiane Grise-Bard,Marie-Christine Brochu,Sylvie Charron,Virender Aulakh,Benoit Bachand,Patrick Beaulieu,Helmi Zaghdane,Sathesh Bhat,Yongxin Han,Joseph P. Vacca,Ian W. Davies,Ann E. Weber,Srikanth Venkatraman

ACS Medicinal Chemistry Letters（2014）

引用27浏览0WOS引用

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