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Our laboratory's major interest is the in the mechanisms responsible for the development and plasticity of precise connections within the central nervous system, and particularly in the role of neural activity in this process. Most of the work of the laboratory is on the visual cortex of the mouse. In our experiments, we induce activity-dependent plasticity experimentally through manipulations of genetics or experience or by pharmacological or neurophysiological intervention in order to discover what cellular mechanisms and what changes in cortical circuitry are responsible for rapid, long lasting changes in neuronal responses. We analyze these changes primarily in alert animals using microelectrode recordings, optical and metabolic signals related to neural activity, and anatomical and neurochemical tracing of connections. We seek to understand the coupling between the physiological and anatomical changes responsible for neuronal plasticity and the cellular mechanisms responsible for activity-dependent plasticity in the neocortex. A major goal is to understand how the limited plasticity in the adult brain differs from the much greater plasticity during critical periods in early life.
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Proceedings of the National Academy of Sciences of the United States of Americano. 6 (2024): e2313596120-e2313596120
Walter R. Mancia Leon,David M. Steffen, Fiona R. Dale-Huang,Benjamin Rakela, Arnar Breevoort, Ricardo Romero-Rodriguez,Andrea R. Hasenstaub,Michael P. Stryker,Joshua A. Weiner,Arturo Alvarez-Buylla
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 6 (2024)
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 4 (2024): e2317773121-e2317773121
bioRxiv : the preprint server for biology (2023)
Neuronno. 5 (2023): 821-834.e4
biorxiv(2023)
Wendy Xin,Megumi Kaneko,Richard H Roth, Albert Zhang, Sonia Nocera,Jun B Ding,Michael P Stryker,Jonah R Chan
bioRxiv : the preprint server for biology (2023)
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