基本信息
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职业迁徙
个人简介
My interest has always been in understanding the nature of brain function and dysfunction, leading ultimately to a career in clinical neurology and neurobiological research. In my clinical practice, my focus is on the diagnosis and treatment of individuals with amyotrophic lateral sclerosis (ALS, Lou Gehrig’s disease). This focus has led to desire to further understand the inherent biology of motor neurons, and how this biology is disturbed in ALS. Ultimately, by gaining this understanding we will be better positioned to develop novel treatment strategies for this devastating disorder.
Research Summary
My clinical research focuses on understanding the natural history of ALS, and in particular the occurrence of “non-motor” manifestations of the disease. Most prominent amongst these are the findings of frontotemporal dysfunction, manifested as a behavioural syndrome, a dysexecutive syndrome, a cognitive syndrome or a florid frontotemporal dementia. We have been specifically interested in the role of advanced neuroimaging techniques in determining who amongst the ALS population is at risk for one or more of these syndromes. In the basic research realm, my research is focused on understanding the neuropathological substrate by which these syndromes occur, leading directly to our research on altered microtubule associated tau protein expression in ALS. Our research into the biology of neurofilament metabolism in ALS has led directly to our discovery of alterations in mRNA metabolism in ALS and the characterization of unique mRNA binding proteins that regulate neurofilament mRNA stability. We have characterized several of these proteins and demonstrated that the protein binding complex responsible for neurofilament mRNA stability is aberrant in ALS – a novel observation with significant biological and therapeutic implications.
研究兴趣
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Cancer medicineno. 19 (2023): 20177-20187
Mark M. Zaki,Rushikesh Sanjeev Joshi,Joseph Raynor Linzey,Michael J. Strong,Timothy Joseph Yee,Yamaan S. Saadeh,Cheerag D. Upadhyaya,Domagoj Coric,Eric A. Potts, Erica Fay Randy Bisson,Jay D. Turner, Jack Knightly,
NEUROSURGERYno. Supplement_1 (2023): 100-100
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World neurosurgery (2023): E403-E409
Springer eBookspp.283-296, (2023)
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Neurosurgical focus: Videono. 1 (2022)
WORLD NEUROSURGERY (2022): E242-E250
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