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Through numerous large-scale longitudinal studies he has earned recognition as a leading researcher in the areas of diabetes mellitus, endocrinology, and cardiovascular disease epidemiology. Steffes is currently principal investigator of the Central Biochemistry Laboratory (CBL) for the Epidemiology of Diabetes Interventions and Complications (EDIC) study, a follow-up to the Diabetes Control and Complications Trial (DCCT) launched in 1984 of which he was also the principal investigator of the CBL. EDIC is a multi-center, longitudinal, observational study designed to use the well-characterized DCCT patient cohort to assess the incidence and predictors of cardiovascular disease events such as heart attack and stroke and diabetic complications related to the eye, kidney, and nerves. In addition, EDIC aims to measure the impact and cost-effectiveness of intensive treatment versus conventional treatment on the quality of life. Steffes is also the principal investigator of the CBL in the GRADE study (Glycemia Reduction Approaches in Diabetes). GRADE is a long-term study with the goal of showing the comparative effectiveness of different treatments for type 2 diabetes, a disease that threatens to become a major public health problem and poses enormous human and economic challenges worldwide.
Dr. Steffes is directing central laboratory testing through ARDL for the Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) study, a multi-center effort exploring the use of novel blood and urine biomarkers to refine the diagnosis and prognosis of patients with acute kidney injury. He is also collaborating with ARDL colleagues to provide central laboratory services for the Coronary Artery Risk Development in Young Adults Study (CARDIA) that examines the development of heart disease in young black and white adults. In addition, he is collaborating in an ongoing effort to standardize the methods to measure hemoglobin A1c (HbA1c), a long-term marker of glycemia. The DCCT/EDIC CBL at the University of Minnesota has defined the measurement of HbA1c in laboratories, both research and clinical. HbA1c is now used to diagnose diabetes mellitus acround the world.
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Diabetes, Obesity and Metabolismno. 7 (2023): 1995-2004
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JAMA Internal Medicineno. 7 (2023): 705-705
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Clinical Journal of the American Society of Nephrologyno. 6 (2019): 854-861
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