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Dr. Brown and his colleague, Dr. Joseph L. Goldstein, discovered the low density lipoprotein (LDL) receptor, which controls cholesterol in blood and in cells. They showed that mutations in this receptor cause Familial Hypercholesterolemia, a disorder that leads to premature heart attacks. Their work laid the groundwork for drugs called statins that block cholesterol synthesis, increase LDL receptors, lower blood cholesterol and prevent heart attacks. Statins are taken daily by more than 20 million people worldwide. Brown and Goldstein shared many awards for this work, including the U.S. National Medal of Science and the Nobel Prize for Medicine or Physiology.
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论文共 671 篇作者统计合作学者相似作者
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The Lancet. Child & adolescent healthno. 7 (2023): 471-478
Albert Henry, Xiaodong Mo,Chris Finan,Mark D. Chaffin,Doug Speed, Hanane Issa,Spiros Denaxas,James S. Ware,Sean L. Zheng,Anders Malarstig,Jasmine Gratton, Isabelle Bond,
medRxiv (Cold Spring Harbor Laboratory) (2023)
British Journal of Cancerno. 10 (2023): 1608-1618
Sean R McCutcheon,Adam M Swartz,Michael C Brown,Alejandro Barrera, Christian McRoberts Amador,Keith Siklenka,Lucas Humayun, Maria A Ter Weele,James M Isaacs,Timothy E Reddy,Andrew S Allen,Smita K Nair,
Nature geneticsno. 12 (2023): 2211-2223
medRxiv : the preprint server for health sciences (2023)
Journal of experimental & clinical cancer research : CRno. 1 (2023): 1-16
bioRxiv (Cold Spring Harbor Laboratory) (2023)
FRONTIERS IN GENETICS (2023): 1235337-1235337
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