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Research in the Sussman lab is focused on developing and applying new genomic technologies to glean mechanistic information on how proteins in the plasma membrane sense and respond to changes in the environment, both externally (e.g. hormones, temperature, light etc) and internally (i.e. developmentally).
Plants respond to environmental changes such as drought by a complex network of signaling proteins whose levels of protein phosphorylation are modulated throughout the cell. The Sussman lab uses mass spectrometric-based quantitative phosphoproteomic pipelines to identify the key components of these signaling networks initiated by hormones and osmosensing receptor proteins at the plant plasma membrane. Arabidopsis thaliana is the model organism under study since it provides facile genetic tests for hypotheses derived from the chemical analyses to ensure that the measured changes play important roles in planta.
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ACS chemical biologyno. 8 (2023): 1786-1796
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Josep Vilarrasa-Blasi,Tamara Vellosillo,Robert Jinkerson, Frieder fauser,Tingting Xiang,Benjamin Minkoff, Lianyong Wang,Kiril Kniazev, Michael Guzman,Jacqueline Osaki,Michael Sussman,Martin Jonikas,
Research Square (Research Square) (2022)
Proceedings of 2022 AOCS Annual Meeting & Expo (2022): 53-53
Food chemistryno. Pt A (2022): 134846-134846
Steven T. Bruckbauer,Benjamin B. Minkoff, Takeshi Shinohara,Anna Lipzen, Jie Guo,Elizabeth A. Wood,Michael R. Sussman,Christa Pennacchio,Michael M. Cox
biorxiv(2021)
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