Michael N. Gwynn

Antibacterial Discovery Performance Unit, Infectious Diseases Center of Excellence in Drug Discovery, GlaxoSmithKline Pharmaceuticals, Collegeville, PA, United States

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Papers20 papers

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Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin

Pan F. Chan,Jianzhong Huang,Haifeng Cui, Minghua Gu, Karen Ingraham, Jason Pizzollo, Carol Shen,Robert A. Stavenger,Michael N. Gwynn,Velupillai Srikannathasan,Andrew P. Fosberry,Michael M. Hann

Nature Communications, (2015)

WOSNATUREBibtex

Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin

Pan F Chan,Velupillai Srikannathasan,Jianzhong Huang, Haifeng Cui,Andrew P Fosberry, Minghua Gu,Michael M Hann,Martin Hibbs,Paul Homes,Karen A Ingraham, Jason Pizzollo,Carol Shen

Nature communications, (2015): 10048-10048

Cited by35WOSBibtex

Recent Developments in Inhibitors of Bacterial Type IIA Topoisomerases

Pan F Chan, Jianzhong Huang, Benjamin D Bax,Michael N Gwynn

(2013)

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Type IIA topoisomerase inhibition by a new class of antibacterial agents

Benjamin D. Bax,Michael M. Hann,Martin R. Saunders,Onkar Singh,Claus E. Spitzfaden,Pan F. Chan,Daniel R. Gentry,Jianzhong Huang,Earl W. May,Carol Shen,Neil D. Pearson,Michael N. Gwynn

Nature, no. 7309 (2010): 935-940

Cited by404WOSNATUREBibtex

Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance

Alexandre Wohlkonig,Pan F Chan,Andrew P Fosberry,Paul Homes,Jianzhong Huang,Michael Kranz,Vaughan R Leydon,Timothy J Miles,Neil D Pearson,Rajika L Perera,Anthony J Shillings,Michael N Gwynn

Nature structural & molecular biology, no. 9 (2010): 1152-1153

Cited by178WOSNATUREBibtex

A rapid microtiter plate assay for measuring the effect of compounds on Staphylococcus aureus membrane potential

Daniel R. Gentry,Imogen Wilding,John M. Johnson,Dongzhao Chen,Katja Remlinger,Cindy Richards,Susan Neill,Magdalena Zalacain,Stephen F. Rittenhouse,Michael N. Gwynn

Journal of Microbiological Methods, no. 2 (2010): 254-256

Cited by10EIWOSBibtex

Challenges of antibacterial discovery revisited: Challenges of antibacterial discovery

Michael N Gwynn, Alison Portnoy, Stephen Rittenhouse,David J Payne

Annals of the New York Academy of Sciences, (2010)

Bibtex

Structural Studies on Bacterial Type IIA Topoisomerases-Targets for Quinolone and Coumarin Antibiotics

Ben Bax,Martin Hibbs, Emma Jones, Andrew Theobald,Andrew Fosberry,Claus Spitzfaden, Anthony Shillings,Alexandre Wohlkonig,Kristin K. Koretke,Jianzhong Huang,Neil Pearson,Michael N. Gwynn

ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, no. SUPnan (2009): S25-S25

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Genetic characterization of Vga ABC proteins conferring reduced susceptibility of Staphylococcus aureus to pleuromutilins

Daniel R Gentry,Lynn Mccloskey,Michael N Gwynn, Stephen Rittenhouse, N Scangarella,Ribhi Shawar,David J Holmes

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, no. 12 (2008): 4507.0-4509.0

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Drugs for bad bugs: confronting the challenges of antibacterial discovery

David J. Payne,Michael N. Gwynn,David J. Holmes,David L. Pompliano

Nature Reviews Drug Discovery, no. 1 (2007): 29-40

Cited by1105WOSNATUREBibtex

Molecular evolution perspectives on intraspecific lateral DNA transfer of topoisomerase and gyrase loci in Streptococcus pneumoniae, with implications for fluoroquinolone resistance development and spread

Michael J Stanhope,Stacey L Walsh,Julie A Becker,Michael J Italia,Karen A Ingraham,Michael N Gwynn,Tom Mathie,James A Poupard,Linda A Miller,James R Brown,Heather Amrine-Madsen

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, no. 10 (2005): 4315-4326

Cited by17WOSBibtex

Novel chromosomally encoded multidrug efflux transporter MdeA in Staphylococcus aureus

Jianzhong Huang,Paul W O'Toole,Wei Shen,Heather Amrine-Madsen,Xinhe Jiang,Neethan Lobo,Leslie M Palmer,LeRoy Voelker,Frank Fan,Michael N Gwynn,Damien McDevitt

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, no. 3 (2004): 909-917

Cited by73WOSBibtex

Enterococcus faecalis acetoacetyl-coenzyme A thiolase/3-hydroxy-3-methylglutaryl-coenzyme A reductase, a dual-function protein of isopentenyl diphosphate biosynthesis

Matija Hedl,Autumn Sutherlin,E Imogen Wilding,Marie Mazzulla,Damien McDevitt,Pamela Lane,John W Burgner,Kevin R Lehnbeuter,Cynthia V Stauffacher,Michael N Gwynn,Victor W Rodwell

Journal of bacteriology, no. 8 (2002): 2116-2122

Cited by59WOSBibtex

IspA from Streptococcus pneumoniae

Michael Gwynn, Edwina Imogen Wilding

(2000)

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PSKG FROM STAPHYLOCOCCUS AUREUS

Wilding Edwina Imogen,Michael Gwynn, Mihaiserban Iordanescu

(2000)

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STAPHYLOCOCCUS AUREUS ispA

Gwynn Michael, Wilding Edwina Imogen

(2000)

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Staphylococcus aureus mvaa

Michael Gwynn, J E Myers, Horn Stephanie Van, Edwina Imogen Wilding

(2000)

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ispA from Staphylococcus aureus

Michael Gwynn, Edwina Imogen Wilding

(2000)

Bibtex

Essentiality, Expression, and Characterization of the Class II 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase ofStaphylococcus aureus

E Imogen Wilding,Dongyul Kim,Alexander P Bryant,Michael N Gwynn,R Dwayne Lunsford,Damien Mcdevitt, J E Myers,Martin Rosenberg, D M Sylvester,Cynthia V Stauffacher,Victor W Rodwell

JOURNAL OF BACTERIOLOGY, no. 18 (2000): 5147-5152

Cited by70Bibtex

Essentiality, Expression, and Characterization of the Class II 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase of Staphylococcus aureus

E. IMOGEN WILDING,DONG-YUL KIM,ALEXANDER P. BRYANT,MICHAEL N. GWYNN,R. DWAYNE LUNSFORD,DAMIEN MCDEVITT,JOSEPH E. MYERS,MARTIN ROSENBERG,DANIEL SYLVESTER,CYNTHIA V. STAUFFACHER,VICTOR W. RODWELL

JOURNAL OF BACTERIOLOGY, no. 18 (2000): 5147-5152

Cited by9WOSBibtex

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