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个人简介
Research and Professional Interests:
Sensory physiology and brain circuits involved in chemosensory communication, including pheromones, studied by electrophysiological, anatomical and behavioral methods.
Current Projects
We study female-to-male and male-to-male signaling in golden hamsters and mice as a model to analyze sensory mechanisms, in particular those leading to sensory control of behavior. Expression of immediate-early gene products such as Fos- and FRA-proteins (from the c-fos gene or related genes) are used as markers to indicate which neurons in the brain change activity under different conditions, including:
Chemosensory Stimulation
Sexual Experience
Hormone/ Neuromodulator Treatment (GnRH, Oxytocin, Dopamine, Androgen)
Direct recording of neuronal electrical activity can also be used in some circumstances.
Our primary interest is in understanding the principles of brain-circuit operation and not the development of therapies, but the unlearned recognition of chemosensory social signals that we study involves brain areas and circuits that have also been implicated in failures to recognize visual social signals, such as facial expressions, as in autism.
Sensory physiology and brain circuits involved in chemosensory communication, including pheromones, studied by electrophysiological, anatomical and behavioral methods.
Current Projects
We study female-to-male and male-to-male signaling in golden hamsters and mice as a model to analyze sensory mechanisms, in particular those leading to sensory control of behavior. Expression of immediate-early gene products such as Fos- and FRA-proteins (from the c-fos gene or related genes) are used as markers to indicate which neurons in the brain change activity under different conditions, including:
Chemosensory Stimulation
Sexual Experience
Hormone/ Neuromodulator Treatment (GnRH, Oxytocin, Dopamine, Androgen)
Direct recording of neuronal electrical activity can also be used in some circumstances.
Our primary interest is in understanding the principles of brain-circuit operation and not the development of therapies, but the unlearned recognition of chemosensory social signals that we study involves brain areas and circuits that have also been implicated in failures to recognize visual social signals, such as facial expressions, as in autism.
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