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His early clinical interests were in the management of acute and chronic kidney failure, helping to adapt hemodialysis and kidney transplantation to infants and small children. His more basic research efforts initially focused primarily on diabetic kidney disease, the cause of nearly half of chronic kidney failure in the Western world. Initially in animal studies and then in research kidney biopsies in humans, he helped to describe the structural changes in the kidney in diabetes that lead to kidney failure. He explored the cellular basis of diabetic kidney disease (DKD) in a series of studies in cells cultured from patients with diabetes. He showed that the structural changes of DKD were reversible by cure of insulin dependent (type 1) diabetes by pancreas transplantation. He was Principle Investigator of two large international multicenter NIH funded clinical treatment trials in type 1 diabetes. In the last 12 years he has also studied a relatively rare form of inherited kidney injury related to Fabry disease and has helped to elucidate the kidney structural basis of this disorder.
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论文共 603 篇作者统计合作学者相似作者
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CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGYno. 1 (2024): 44-55
The Journal of clinical endocrinology and metabolism (2024)
KIDNEY INTERNATIONALno. 1 (2024): 165-176
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGYno. 12 (2023): 1953-1964
Springer eBookspp.817-830, (2023)
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The Journal of clinical investigationno. 11 (2023)
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Endocrinesno. 3 (2023): 548-557
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Molecular Genetics and Metabolismno. 2 (2023): 107234
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