Dr. Fine’s overarching research program has focused on ways to improve the quality and equity of medical care for patients with common medical problems. His research has employed retrospective and prospective cohort designs, with extensive emphasis on patient-centered outcomes. He has also designed and directed large-scale cluster - randomized trials to test the effectiveness and safety of medical practice guidelines to improve the quality and efficiency of care for patients with common medical illnesses. Dr. Fine has published over 300 original scientific manuscripts and peer-review articles and commentaries.