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Our research efforts are aimed at understanding how retroviruses assemble and how they specifically recognized and package their genetic material. Over the past decade or so, we and others have determined the 3D structures of several isolated protein components that make up HIV-1 (the retrovirus that causes AIDS). We now wish to understand how these components interact with each other and with cellular constituents. We are also interested in understanding how these intermolecular interactions change when the initially-formed retrovirus matures and become infectious. In the long term, we would like to use the basic structural and functional information obtained to design new therapeutic approaches for the treatment of AIDS and other human diseases caused by retroviruses.
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论文共 177 篇作者统计合作学者相似作者
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PROTEIN SCIENCE (2023)
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Jennifer A. White,Fengting Wu,Saif Yasin,Milica Moskovljevic,Joseph Varriale,Filippo Dragoni,Angelica Camilo-Contreras,Jiayi Duan,Mei Y. Zheng,Ndeh F. Tadzong, Heer B. Patel, Jeanelle Mae C. Quiambao,
Virusesno. 3 (2021): 453
J.B. Brown, H.R. Summers,L.A. Brown, J. Marchant, P.N. Canova, C.T. O'Hern, S.T. Abbott, C. Nyaunu, S. Maxwell, T. Johnson, M.B. Moser, H. Carter,
semanticscholar(2020)
J.B. Brown, H.R. Summers,L.A. Brown,J. Marchant, P.N. Canova, C.T. O'Hern, S. Abbott, C. Nyaunu, S. Maxwell, T. Johnson,M. Moser,S.D. Ablan,
Janae B. Brown, Holly R. Summers,Lola A. Brown, Jan Marchant, Paige N. Canova,Colin T. O'Hern, Sophia T. Abbott, Constance Nyaunu, Simon Maxwell, Talayah Johnson, Morgan B. Moser,Sherimay D. Ablan,
Journal of Molecular Biologyno. 14 (2020): 4076-4091
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