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职业迁徙
个人简介
Our research focuses on cellular and molecular mechanisms of frontotemporal dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS), two related neurodegenerative disorders. We use a combination of cell biology, proteomic, and functional genomic approaches in iPSC neuron models of ALS/FTD, with a long-term goal of understanding how disease-associated familial mutations lead to neurodegeneration. Our group has made several major contributions to the field over the past several years: 1) New tools that enable large-scale production of human iPSC-derived neurons and genome-wide CRISPRi screens, and conception and management of a large-scale genome engineering iPSC initiative (iNDI). 2) Discovery of a new mechanism of axonal RNA transport in neurons that involves lysosomal hitchhiking, a process that goes awry in familial ALS. 3) Characterization of dysregulated splicing in ALS/FTD due to mislocalization of TDP-43, uncovering novel disease-relevant splicing targets and potential biomarkers. 4) Discovery of widespread DNA break/repair events at neuronal enhancers that are likely necessary for epigenetic regulation. Each of these efforts have been highly collaborative in nature, involving multiple teams from independent institutions. Please visit https://research.ninds.nih.gov/ward-lab/publications for a more complete list of recent publications and team collaborations.
研究兴趣
论文共 236 篇作者统计合作学者相似作者
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biorxiv(2024)
SCIENCE TRANSLATIONAL MEDICINEno. 734 (2024)
Anna Calliari,Lillian M. Daughrity, Ellen A. Albagli, Paula Castellanos Otero,Mei Yue,Karen Jansen-West, Naeyma N. Islam,Thomas Caulfield, Bailey Rawlinson,Michael DeTure,Casey Cook,Neill R. Graff-Radford,
Molecular Neurodegenerationno. 1 (2024): 1-5
Aaron Held,Michelle Adler,Christine Marques, Charles Jourdan Reyes,Amey S Kavuturu, Ana R A A Quadros,I Sandra Ndayambaje, Erika Lara,Michael Ward,Clotilde Lagier-Tourenne,Brian J Wainger
Cell reportsno. 9 (2023): 113046-113046
PLoS biologyno. 3 (2023): e3002028-e3002028
Cell Reports Methodsno. 10 (2023): 100593-100593
Frontiers in aging (2023): 1191993
Allison Snyder,Veronica H Ryan,James Hawrot, Sydney Lawton,Daniel M Ramos, Y Andy Qi,Kory Johnson,Xylena Reed, Nicholas L Johnson,Aaron W Kollasch,Megan Duffy,Lawren VandeVrede,
Research square (2023)
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