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Dr. Pichichero’s lab is focused on prospective, longitudinal clinical and translational studies of acute otitis media (AOM) (R01 DC 08671). His group seeks to define the adaptive and innate immune response deficits among otitis prone (OP) children to infections caused by nontypeable Haemophilus influenzae (NTHi) and Streptococcus pneumoniae (Spn). They seek to understand the immunity deficits among OP children in the context of overcoming the immune modulating effects of upper respiratory viral infections. To better understand NTHi and Spn pathogenesis and assist in vaccine development they are: (1) identifying specific adaptive immune deficits in OP children; (2) determining independent contributions of mucosal immunity in OP children; (3) understanding the role of innate responses to co-infection of respiratory bacteria and viruses; and (4) defining the role of differences in the nasopharyngeal (NP) inflammatory response in shaping the mucosal microenvironment to allow for NTHi/Spn colonization and then infection.
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PEDIATRIC INFECTIOUS DISEASE JOURNALno. 3 (2024): 294-300
Ravinder Kaur, Ryan Gierke, Lesley McGee,Eduardo Gonzalez, Miwako Kobayashi,Michael Pichichero, Active Bacterial Core surveillance Team
Seth P Jones,Kali H Cook,Melody L Holmquist, Liam J Almekinder,Annie M Delaney, Ryhl Charles,Natalie Labbe,Janai Perdue,Niaya Jackson,Michael E Pichichero,Ravinder Kaur,Lea V Michel,
Michael Shaffer, Katharine Best,Catherine Tang,Xue Liang, Steven Schulz,Eduardo Gonzalez,Cory H. White,Thomas P. Wyche,John Kang, Hendrik Wesseling,Beguem D. Topcuoglu, Thomas Cairns,
Journal of the Pediatric Infectious Diseases Societyno. 3 (2023): 135-142
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Cellular immunology (2023): 104777-104777
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