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个人简介
Dr. Michael Cox is a molecular and cellular biologist who earned his PhD in Biochemistry from the University of North Carolina for studies on how oncogenes impact neuronal growth and differentiation. He began his work on cell signaling networks in prostate cancer at the University of Virginia. His research program is dedicated to understanding how prostate cancer, the most frequently diagnosed male malignancy, initiates and progresses and to finding ways of halting advanced disease progression.
Dr. Cox’s research is funded by the Terry Fox Foundation, Canadian Cancer Society, the VGH & UBC Hospital Foundation and the Prostate Cancer Foundation of British Columbia. His work focuses on early genetic changes in prostate cells, how resulting tumor cells respond to growth factors in the presence or absence of testosterone and how these cellular changes allow prostate tumor cells to utilize these growth factors to aid development of testosterone independence. With colleagues at the Vancouver Prostate Centre and University of British Columbia, he is developing combinatorial antisense and small molecule drug strategies that decrease the responsiveness of tumor cells to growth factors and has shown that prostate cancer cells treated in this way are more sensitive to testosterone deprivation or treatment with other chemotherapies. These are first steps in developing effective treatments for patients with advanced prostate cancer.
Dr. Cox’s research is funded by the Terry Fox Foundation, Canadian Cancer Society, the VGH & UBC Hospital Foundation and the Prostate Cancer Foundation of British Columbia. His work focuses on early genetic changes in prostate cells, how resulting tumor cells respond to growth factors in the presence or absence of testosterone and how these cellular changes allow prostate tumor cells to utilize these growth factors to aid development of testosterone independence. With colleagues at the Vancouver Prostate Centre and University of British Columbia, he is developing combinatorial antisense and small molecule drug strategies that decrease the responsiveness of tumor cells to growth factors and has shown that prostate cancer cells treated in this way are more sensitive to testosterone deprivation or treatment with other chemotherapies. These are first steps in developing effective treatments for patients with advanced prostate cancer.
研究兴趣
论文共 218 篇作者统计合作学者相似作者
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Chris Zhou, NAOMI JUNG,SAMUEL XU, FELIPE ELTIT GUERSETTI, Xin Lu,QIONG WANG, DORIS LIANG,COLM MORRISSEY,EVA COREY,LAWRENCE TRUE,Rizhi Wang,Shuo Tang,
biorxiv(2024)
Peter Ruzanov,Valentina Evdokimova, Manideep C Pachva, Alon Minkovich,Zhenbo Zhang,Sofya Langman,Hendrik Gassmann,Uwe Thiel,Marija Orlic-Milacic, Syed H Zaidi, Vanya Peltekova,Lawrence E Heisler,
The Journal of clinical investigation (2024)
Gerhardt Attard,Joost F. Swennenhuis,David Olmos,Alison H.M. Reid,Elaine Vickers, Roger A'Hern, Rianne Levink,Frank Coumans, Joana Moreira,Ruth Riisnaes,Nikhil Babu Oommen, George Hawche,
crossref(2023)
Maryam Moussavi,Ladan Fazli, Howard Tearle,Yubin Guo,Michael Cox,John Bell,Christopher Ong,William Jia,Paul S. Rennie
crossref(2023)
Abigail Cunningham, Maddisen Brown,Jonathan Dresselhuis,Nicole Robinson, Keni Hervie,Michael E. Cox,Julia Mills
BIOLOGY-BASELno. 7 (2023): 906-906
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Maryam Moussavi,Ladan Fazli, Howard Tearle,Yubin Guo,Michael Cox,John Bell,Christopher Ong,William Jia,Paul S. Rennie
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Maryam Moussavi,Ladan Fazli, Howard Tearle,Yubin Guo,Michael Cox,John Bell,Christopher Ong,William Jia,Paul S. Rennie
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Jacob A. Gordon, Jake W. Noble,Ankur Midha,Fatemeh Derakhshan,Gang Wang,Hans H. Adomat,Emma S. Tomlinson Guns,Yen-Yi Lin,Shancheng Ren, Collin C. Collins,Peter S. Nelson,Colm Morrissey,
crossref(2023)
Maryam Moussavi,Ladan Fazli, Howard Tearle,Yubin Guo,Michael Cox,John Bell,Christopher Ong,William Jia,Paul S. Rennie
crossref(2023)
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