Michael Bubser - Universität Tübingen Abteilung Neuropharmakologie Mohlstrasse 54/1 D-72074 Tübingen Germany Mohlstrasse 54/1 D-72074 Tübingen Germany

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Discovery of Pre-Clinical Candidate VU6008055/AF98943: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust in Vivo Efficacy

Julie L Engers,Sean R Bollinger, Alison R Gregro, Rory A Capstick, Paul K Spearing,Madeline F Long,James C Tarr, Katherine J Watson, Sichen Chang,Vincent B Luscombe,Alice L Rodriguez,Hyekyung P Cho,Aidong Qi, Colleen M Niswender,Michael Bubser,Robert W Gould, William Hudson Robb,Nellie Byun, John Gore,Carrie K Jones, Morten S Thomsen,Thomas M Bridges,Olivier Boutaud,P Jeffrey Conn,Darren W Engers,Craig W Lindsley,Kayla J Temple

ACS chemical neuroscienceno. 11 (2025): 2141-2162

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Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Effects of the Muscarinic M 1 Positive Allosteric Modulator VU0467319 for Alzheimer's Disease: A Single Ascending-Dose Study in Healthy Participants

Alexander C Conley,Alexandra P Key, Jennifer U Blackford, Jason K Russell, Kimberly M Albert, Xuewen Gong,Michael Bubser,Jerri M Rook,P Jeffrey Conn,Craig W Lindsley,Carrie K Jones, Paul A Newhouse

Research square (2025)

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Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M5 Muscarinic Acetylcholine Receptor

Jinming Li,Douglas L. Orsi,Julie L. Engers,Madeline F. Long,Rory A. Capstick, Mallory A. Maurer,Christopher C. Presley,Paige N. Vinson,Alice L. Rodriguez, Allie Han,Hyekyung P. Cho,Sichen Chang,Megan Jackson,Michael Bubser,Anna L. Blobaum,Olivier Boutaud,Michael A. Nader,Colleen M. Niswender,P. Jeffrey Conn,Carrie K. Jones,Craig W. Lindsley,Changho Han

Journal of Medicinal Chemistry (2024)

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Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM)

Julie L. Engers, Logan A. Baker,Sichen Chang,Vincent B. Luscombe,Alice L. Rodriguez,Colleen M. Niswender,Hyekyung P. Cho,Michael Bubser,Analisa Thompson Gray,Carrie K. Jones,Weimin Peng,Jerri M. Rook,Thomas M. Bridges,Olivier Boutaud,P. Jeffrey Conn,Darren W. Engers,Craig W. Lindsley,Kayla J. Temple

ACS CHEMICAL NEUROSCIENCEno. 20 (2024): 3744-3754

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The Evolving Role of Animal Models in the Discovery and Development of Novel Treatments for Psychiatric Disorders

Laura B Teal,Shalonda M Ingram,Michael Bubser,Elliott McClure,Carrie K Jones

Advances in neurobiologypp.37-99, (2023)

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The M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0467154 Normalizes Non‐rapid Eye Movement Sleep Deficits in Non‐pathologically Aged Mice

Jason K Russell, Laura Wan,Shalonda Ingram,Michael Bubser,Craig W Lindsley,Carrie K Jones

Alzheimer's &amp Dementiano. S21 (2023)

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Selective M5 Muscarinic Acetylcholine Receptor Negative Allosteric Modulator VU6008667 Blocks Acquisition of Opioid Self-Administration

Laura B. Teal,Michael Bubser, Edith Duncan,Robert W. Gould,Craig W. Lindsley,Carrie K. Jones

Neuropharmacology (2023): 109424-109424

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The M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) VU0453595 and M4 PAM VU0467154 Normalize Sleep‐Wake Architecture Deficits in Aged Mice

Jason K Russell,Michael Bubser,Shalonda Ingram,Paul A Newhouse,Craig W Lindsley,Carrie K Jones

Alzheimer's &amp Dementia（2022）

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Age and Circadian Rhythm‐dependent Effects of M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulators and Donepezil on Sleep‐wake Architecture and Arousal

Jason K Russell,Michael Bubser,Paul A Newhouse,Craig W Lindsley,Carrie K Jones

Alzheimer s & Dementiano. S9 (2021)

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