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Neurones communicate at structures called synapses, which are tiny gaps between neurones where chemical signals are passed. These chemicals are called neurotransmitters and they are packaged inside synaptic vesicles.
Synaptic vesicles (SVs) live locally at one side of the synapse called the presynapse or nerve terminal. Upon nerve stimulation synaptic vesicles fuse with the presynaptic plasma membrane and release their neurotransmitter into the synapse, stimulating the neuron on the other side of the synapse (postsynapse). After release of neurotransmitter, the vesicle membrane is retrieved by a process called endocytosis, refilled with neurotransmitter then trafficked locally within the nerve terminal to be released again.
My research investigates how presynaptic function adapts to maintain neurotransmission across the range physiological inputs. This includes recruitment of specific SV endocytosis modes and SV cargo retrieval mechanisms. To answer these questions we use a multi-disciplinary approach employing a variety of in vitro model systems which combine population and single cell fluorescent imaging of nerve terminals with functional, biochemical, cell biological and molecular biological techniques. We are increasingly making use of preclinical disease models to determine how dysfunctional SV recycling can impact on synaptic failure.
Synaptic vesicles (SVs) live locally at one side of the synapse called the presynapse or nerve terminal. Upon nerve stimulation synaptic vesicles fuse with the presynaptic plasma membrane and release their neurotransmitter into the synapse, stimulating the neuron on the other side of the synapse (postsynapse). After release of neurotransmitter, the vesicle membrane is retrieved by a process called endocytosis, refilled with neurotransmitter then trafficked locally within the nerve terminal to be released again.
My research investigates how presynaptic function adapts to maintain neurotransmission across the range physiological inputs. This includes recruitment of specific SV endocytosis modes and SV cargo retrieval mechanisms. To answer these questions we use a multi-disciplinary approach employing a variety of in vitro model systems which combine population and single cell fluorescent imaging of nerve terminals with functional, biochemical, cell biological and molecular biological techniques. We are increasingly making use of preclinical disease models to determine how dysfunctional SV recycling can impact on synaptic failure.
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Brain : a journal of neurology (2024)
Eva-Maria Blumrich, Jessica C. Nicholson-Fish,Marie Pronot,Elizabeth C. Davenport,Dominic Kurian,Adam Cole,Karen J. Smillie,Michael A. Cousin
Cell reportsno. 6 (2023): 112633
biorxiv(2023)
Y. Imoto,S. Raychaudhuri, Y. Ma,P. Fenske,E. Sandoval,K. Itoh,E. Blumrich, H. T. Matsubayashi,L. Mamer,F. Zarebidaki, B. Soehl-Kielczynski,T. Trimbuch,
Margherita Caputo,Daniela Ivanova,Sylvette Chasserot-Golaz, Frédéric Doussau,Anne-Marie Haeberlé,Sebahat Ozkan, Jason Ecard,Marie-France Bader,Nicolas Vitale,Michael A. Cousin,Petra Tóth,Stéphane Gasman,
biorxiv(2023)
The Journal of neuroscience : the official journal of the Society for Neuroscienceno. 11 (2023): 2002-2020
Eva-Maria Blumrich, Jessica C. Nicholson-Fish,Marie Pronot,Elizabeth C. Davenport,Dominic Kurian,Adam R. Cole,Karen J. Smillie,Michael A. Cousin
Cell Reportsno. 6 (2023): 112633-112633
K. Bonnycastle, K.L. Dobson, E-M. Blumrich,A. Gajbhiye, E.C. Davenport,M. Pronot, M. Steinruecke,M. Trost, A. Gonzalez-Sulser,M.A. Cousin
biorxiv(2023)
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