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Much of his research focused on understanding antibiotic production and its regulation in actinomycetes, the major source of clinically useful antibiotics. The resulting knowledge was used not only to understand how these complex molecules are made, but also to engineer the producing organisms to make potentially improved derivatives.
Genome sequencing has revealed that actinomycetes have the potential to produce many more natural products than previously thought; he also focused on the activation of these silent biosynthetic gene clusters leading to the discovery of novel compounds with anti-bacterial activity.
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Yin Yao Dong,Hua Wang,Ashley C.W. Pike, Stephen A. Cochrane,Sadra Hamedzadeh, Filip J. Wyszyński,Simon R. Bushell, Sylvain F. Royer,David A. Widdick,Andaleeb Sajid,Helena I. Boshoff,Ricardo Lucas,
biorxiv(2018)
Yin Yao Dong,Hua Wang,Ashley C. W. Pike,Stephen A. Cochrane,Sadra Hamedzadeh, Filip J. Wyszyyski,Simon R. Bushell, Sylvain F. Royer,David A. Widdick,Andaleeb Sajid,Helena I. Boshoff,Ricardo Lucas,
SSRN Electronic Journal (2018)
semanticscholar(2017)
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MARINE DRUGSno. 4 (2016): 78
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