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My research focuses on improving our understanding of the cellular responses mediated by G Protein-Coupled Receptors (GPCRs) with particular focus on novel emerging paradigms that challenge the traditional views on GPCR signalling and regulation and promise to change the way drugs are screened and validated. Such two inter-related paradigms in GPCR biology are: GPCR positional dynamism (encompassing GPCR regulation and compartmentalised signalling) and GPCR conformational dynamism (namely allosterism and biased agonism). The general premise of my work is that a greater understanding of the mechanisms of action of GPCRs will lead to novel, more efficacious, GPCR-targeted therapeutics.
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论文共 148 篇作者统计合作学者相似作者
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Sina B. Kirchhofer,Victor Jun Yu Lim, Sebastian Ernst, Noemi Karsai, Julia G. Ruland,Meritxell Canals,Peter Kolb,Moritz Buenemann
BRITISH JOURNAL OF PHARMACOLOGYno. 4 (2023): 484-485
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
Journal of medicinal chemistryno. 15 (2023): 10304-10341
Rob Hill,Julie Sanchez,Laura Lemel, Mirjana Antonijevic, Yselkla Hosking,Shailesh N Mistry,Andrew C Kruegel,Jonathan A Javitch,J Robert Lane,Meritxell Canals
British journal of pharmacologyno. 24 (2023): 3160-3174
Owen Underwood, Sebastian Frizwanker, Jaqueline Glenn, Arisbel Batista-Gondin,Julia Drube,Carsten Hoffmann,Stephen J Briddon, Stefan Stefan Schulz,Meritxell Canals
biorxiv(2023)
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2022)
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