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My research group is interested in synthesising novel carbene-metal antibiotics and titanocene anticancer drugs in order to evaluate them biologically in cell tests and mouse models. Additionally we want to get an insight into the mechanism of action from a biological and chemical point of view. The targets for our titanocenes are breast and renal cell cancer, while the carbene-metal antibiotics are to be developed into resistance-breaking antibiotics targeting difficult bacteria like MRSA.
My research group is interested in synthesising novel carbene-metal antibiotics and titanocene anticancer drugs in order to evaluate them biologically in cell tests and mouse models. Additionally we want to get an insight into the mechanism of action from a biological and chemical point of view. The targets for our titanocenes are breast and renal cell cancer, while the carbene-metal antibiotics are to be developed into resistance-breaking antibiotics targeting difficult bacteria like MRSA.
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Bernadette Sarah Creaven, Erika Mooney,Matthias Tacke, Helge Mueller-Bunz, Julia Bruno-Colmenarez,Gordon Cooke, Emma Caraher, Fintan Kelleher
crossref(2024)
RSC medicinal chemistryno. 7 (2023): 1260-1271
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Metallomicsno. 8 (2022)
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Hao Chen,Qianqian Lu, Haoyue An, Juntong Li, Shuchu Shen,Xi Zheng,Wei Chen,Lu Wang, Jihong Li, Youqin Du, Yueqing Wang,Xiaowen Liu,
Jennie O'Loughlin,Silvia Napolitano, Fahad Alkhathami,Cillian O'Beirne, Daniel Marhöfer,Megan O'Shaughnessy,Orla Howe,Matthias Tacke,Marina Rubini
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