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Research interest:
Vaccines: One focus of the Schnell laboratory are Rhabdovirus-based vectors as vaccines against other infectious diseases.
• Rabies viruses (RABV) based vaccines are promising as both live and killed vaccines against infectious disease. This is based on that RABV vectors are highly immunogenic and combine a necessary vaccine with limited financial resources for development (such as EBOV) with a safe, approved, and financially practical vaccine (RABV)
• Using different molecular approaches, we perform detailed studies of highly attenuated rabies virus (RABV) RABV expressing filovirus (e.g. Ebola Virus (EBOV) and Marburg virus (MARV)) glycoproteins and analyze their immunogenicity in mice and non-human primates (NHP). The most promising filovirus virus vaccine candidates are currently further studied in NHP
• Novel vaccines against Hendra and Nipha virusesThe goal is the development of this vaccine platform for human but also to immunize animals to break the transmission cycle of this zoonotic disease.
Viral pathogenicity: We are interested in a detailed understanding of the biochemistry, molecular biology and immunology of rabies virus and its interaction with the infected host. The molecular mechanism of rabies virus pathogenesis is not well understood and our research analyses the different functions the rhabdoviral proteins (e.g. rabies virus) and their interaction with cellular host proteins.
Current projects are directed to:
Innate immunity (e.g. the interferon sensitive Ifit genes) and there function for RABV virus neurotropism
Vaccines: One focus of the Schnell laboratory are Rhabdovirus-based vectors as vaccines against other infectious diseases.
• Rabies viruses (RABV) based vaccines are promising as both live and killed vaccines against infectious disease. This is based on that RABV vectors are highly immunogenic and combine a necessary vaccine with limited financial resources for development (such as EBOV) with a safe, approved, and financially practical vaccine (RABV)
• Using different molecular approaches, we perform detailed studies of highly attenuated rabies virus (RABV) RABV expressing filovirus (e.g. Ebola Virus (EBOV) and Marburg virus (MARV)) glycoproteins and analyze their immunogenicity in mice and non-human primates (NHP). The most promising filovirus virus vaccine candidates are currently further studied in NHP
• Novel vaccines against Hendra and Nipha virusesThe goal is the development of this vaccine platform for human but also to immunize animals to break the transmission cycle of this zoonotic disease.
Viral pathogenicity: We are interested in a detailed understanding of the biochemistry, molecular biology and immunology of rabies virus and its interaction with the infected host. The molecular mechanism of rabies virus pathogenesis is not well understood and our research analyses the different functions the rhabdoviral proteins (e.g. rabies virus) and their interaction with cellular host proteins.
Current projects are directed to:
Innate immunity (e.g. the interferon sensitive Ifit genes) and there function for RABV virus neurotropism
研究兴趣
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NPJ vaccinesno. 1 (2023): 10-10
Springer eBookspp.15-41, (2023)
Research Square (Research Square) (2022)
Research Square (Research Square) (2022)
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