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个人简介
Matthew’s research is in field of gene therapy for degenerative disorders of the nervous system and muscle. The main focus is the investigation of novel therapeutic approaches utilising short nucleic acids to target messenger RNA. Targeting RNA has the potential to allow modification of the target transcript, reprogramming of endogenous genetic defects or the targeting of specific disease alleles, all the while maintaining endogenous regulation of the target gene. Current work is investigating the potential of single-stranded antisense oligonucleotides for the modification of mRNA splicing, for example in Duchenne muscular dystrophy. In addition, the potential of double-stranded RNA for gene silencing, known as RNA interference (RNAi), is being investigated for the silencing of target genes and mutant alleles both in muscle and in the nervous system. In particular, RNAi has great potential as a future therapeutic agent for currently untreatable neurodegenerative disorders such as Parkinson’s disease.
研究兴趣
论文共 339 篇作者统计合作学者相似作者
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Scott E. Bonner, Simonides I. van deWakker, William Phillips,Eduard Willms,Joost P. G. Sluijter, Andrew F. Hill,Matthew J. A. Wood,Pieter Vader
Journal of Extracellular Biologyno. 2 (2024): n/a-n/a
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Jessica Stoodley, Francisco Vallejo-Bedia, David Seone-Miraz, Manuel Debasa-Mouce,Matthew J A Wood,Miguel A Varela
EMBO molecular medicineno. 11 (2023): n/a-n/a
Journal of medicinal chemistryno. 13 (2023): 9223-9224
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