My laboratory is interested in the development and characterization of animal models of human neurodegenerative diseases, particularly Cerebral amyloid angiopathy (CAA), Alzheimer and Parkinson diseases.

In addition to the activities of my laboratory, I am the faculty coordinator for the tissue-based activities of the Harvard NeuroDiscovery Center (HNDC). We design the implementation of programs that can support tissue-based research into a wide range of neurodegenerative disorders, as pursued across the Harvard neuroscience community (including basic and clinical investigations). Among the resources we have developed is the Advanced Tissue Resource Center, based in Building 114, which includes a staffed Laser Capture Microdissection facility that is available to users.

I direct the Neuropathology Core of the NIA-supported MA Alzheimer Disease Research Center (MADRC). The Core provides diagnostic and research-oriented neuropathology autopsy services in support of the Clinical Core of the MADRC. It also provides tissue to a wide range of researchers within the institution, across the country and internationally.