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Our lab works on the clinical and molecular aspects of solid tumours of childhood, particularly germ cell tumours (GCTs) – of which testicular cancer is the most common form. Our work has established emphasis on the role of non-coding RNAs such as microRNAs, which are short, non-protein-coding RNAs that regulate gene expression post-transcriptionally and are aberrantly expressed in cancer. We demonstrated for the first time that the miR-371~373 and miR-302/367 clusters are highly over-expressed in all malignant GCTs, regardless of patient age, histological subtype or anatomical site (published in Cancer Research in 2010). This is a specific change, as these microRNAs are not co-ordinately dysregulated in any other malignancy or disease state. We subsequently were the first to demonstrate the potential utility of specific circulating microRNAs for diagnosis, disease-monitoring and detection of relapse in GCTs as well as other childhood tumours.
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EJC Paediatric Oncology (2024): 100146
Farzana Pashankar,Matthew J. Murray,Joanna Gell,Nicola MacDonald,Jonathan Shamash, Deborah F. Billmire, Lindsay Klosterkemper,Thomas Olson,Michelle S. Hirsch,Michelle Lockley,Sara Stoneham,A. Lindsay Frazier
eClinicalMedicine (2024): 102453-102453
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Matthew J. Murray, Harpreet K. Saini, Charlotte A. Siegler, Jennifer E. Hanning,Emily M. Barker,Stijn van Dongen,Dawn M. Ward, Katie L. Raby,Ian J. Groves,Cinzia G. Scarpini,Mark R. Pett,Claire M. Thornton,
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JOURNAL OF UROLOGY (2023): E456-E456
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Nature Reviews Urologyno. 8 (2023): 459-460
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JOURNAL OF CLINICAL ONCOLOGYno. 16 (2023): TPS5104-TPS5104
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Luz Alonso-Crisostomo, Jennifer Trendell,Marta Ferraresso,Shivani Bailey,Dawn Ward,Zachary G L Scurlock, Stephanie C Wenlock,Carlos A P Bastos,Ravin Jugdaohsingh,Nuno J Faria,Anton J Enright,Cinzia G Scarpini,
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