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职业迁徙
个人简介
My overall research goal is to create therapeutic interventions for viruses of public health concern by developing a detailed understanding of how the viruses interact with the host. My research has focused on the recently emerged and highly pathogenic coronaviruses: Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2/COVID19), as well as Influenza virus. The coronaviruses cause severe lung disease, are highly lethal and yet there are no FDA approved therapeutics that target them.
Important to understanding these diseases has been our development, characterization and utilization of mouse models of disease for SARS-CoV, MERS-CoV and SARS-CoV-2. The rapid and successful development of these models has allowed us to unravel the cellular and physiological basis for disease of these viruses. In addition, the creation of these models has allowed for therapeutic development of vaccines, antibodies, small molecules, novel and repurposed drugs and other therapeutics. Critical to my research is the synergy of our in vitro and in vivo models of disease that allow us deep understandings of how these viruses work.
Important to understanding these diseases has been our development, characterization and utilization of mouse models of disease for SARS-CoV, MERS-CoV and SARS-CoV-2. The rapid and successful development of these models has allowed us to unravel the cellular and physiological basis for disease of these viruses. In addition, the creation of these models has allowed for therapeutic development of vaccines, antibodies, small molecules, novel and repurposed drugs and other therapeutics. Critical to my research is the synergy of our in vitro and in vivo models of disease that allow us deep understandings of how these viruses work.
研究兴趣
论文共 182 篇作者统计合作学者相似作者
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medRxiv (Cold Spring Harbor Laboratory)no. 2 (2024): ofad625-ofad625
biorxiv(2023)
Jianyu Lai,Kristen K. Coleman,S. H. Sheldon Tai,Jennifer German,Filbert Hong,Barbara Albert, Yi Esparza, Aditya K. Srikakulapu,Maria Schanz, Isabel Sierra Maldonado, Molly Oertel, Naja Fadul,
CLINICAL INFECTIOUS DISEASESno. 5 (2023): 786-794
PLOS PATHOGENSno. 12 (2023): e1011870
bioRxiv (Cold Spring Harbor Laboratory) (2023)
NPJ VACCINESno. 1 (2023)
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