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Her research interests focus on the biology of stem cells and the development of innovative medicines and tissue engineering solutions for osteoarthritis, bone repair and vascular calcification. Her basic research is focused on the concept that stem cell depletion or alteration of function contribute to the development of chronic degenerative diseases such as osteoarthritis and atherosclerosis. The use of the chondrogenic differentiation pathway of bone marrow-derived MSCs as a model to study early changes in osteoarthritis development and the role of inflammation and epigenetics in disease progression is a central platform of her research. Applied research has a focus on cell manufacturing technologies including automation, robotic processes, scalable systems and novel xeno-free and defined cell expansion media. Mary Murphy has contributed to the fields of tissue engineering and regenerative medicine with particular impact on the development of cell therapies for osteoarthritis. Publications span basic, translational and manufacturing research in the areas of mesenchymal stromal cell biology, cartilage repair and cell therapy (>14700 citations, h-index 46 – Dec 2019).
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论文共 251 篇作者统计合作学者相似作者
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Matteo Rovere,Matilde Balbi,Sara Santamaria,Vanessa Cossu,Daniele Reverberi,Emanuele Quarto,Matteo Formica, Silvia Pontara,Georgina Shaw, Milena Mastrogiacomo,Silvia Ravera,Simona Coco,
Osteoarthritis and Cartilage (2024): S319
Matteo Rovere,Matilde Balbi,Sara Santamaria,Vanessa Cossu,Daniele Reverberi,Emanuele Quarto,Matteo Formica, Silvia Pontara,Georgina Shaw, Milena Mastrogiacomo,Silvia Ravera,Simona Coco,
Osteoarthritis and Cartilage (2024)
TISSUE ENGINEERING PART Ano. 13-14 (2023)
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Osteoarthritis and Cartilageno. 13-14 (2023): S229-S229
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TISSUE ENGINEERING PART Ano. 11-12 (2023): 567-568
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Cytotherapyno. 6 (2023): S274-S274
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FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023): 1209047-1209047
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