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The current focus of Dr. Goldring’s laboratory is on the mechanisms of gene regulation by which stress- and inflammation-induced signals induce expression of matrix metalloproteinase 13 (MMP-13), the pivotal collagen-degrading proteinase that marks osteoarthritis progression, as well as other catabolic and anabolic responses in cartilage and other joint tissues. Her laboratory has found that there are common mediators of these processes in human OA cartilage that are also involved in mechanotransduction, including the protein kinases, IKKs and MAPKs. These pathways converge on transcriptional regulation of MMP13, IL1B, and other key genes by NF-kB, Elf3, C/EBPb, Runx2, and hypoxia-inducible factor (HIF) 2a.
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Ningrong Chen,Xin Wei,Gang Zhao,Zhenshan Jia, Xin Fu,Haochen Jiang,Xiaoke Xu,Zhifeng Zhao, Purva Singh, Samantha Lessard,Miguel Otero,Mary B. Goldring,
Nanomedicine : nanotechnology, biology, and medicine (2024): 102735-102735
Ningrong Chen,Xin Wei,Gang Zhao,Zhenshan Jia, Xin Fu,Haochen Jiang,Xiaoke Xu,Zhifeng Zhao, Purva Singh, Samantha Lessard,Miguel Otero,Mary B. Goldring,
Science signalingno. 809 (2023)
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