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Professor Hewison’s work focuses on different facets of vitamin D physiology, including classical skeletal effects and non-classical extra-skeletal effects. He has a particular interest in the interaction between vitamin D and the immune system, where antigen-presenting cells such as dendritic cells and macrophages synthesize active vitamin D (calcitriol) and also express the nuclear receptor for calcitriol (VDR). Vitamin D can therefore act as an endogenous regulator of both innate and adaptive immunity by enhancing antibacterial activity, and modulating antigen presentation and T lymphocyte function. Crucially these responses are highly dependent on the bioavailability of vitamin D, and Professor Hewison has hypothesized that immune function is influenced by vitamin D status in humans. His group is using a variety of models to test this hypothesis including basic molecular and cell analyses, and vitamin D supplementation trials in human cohorts. A key objective of his work is to increase awareness of vitamin D-deficiency in the UK population.
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John S. Adams,Karin Amrein,Paul Anderson, Leggy A. Arnold,Juhi Arora, Patricio Artusa,Alberto Ascherio, Niels C. Asmussen, Anne Astier, Min Ji Bak, Kevin T. Bauerle, Anna Y. Belorusova,
Elsevier eBookspp.xxvii-xxxiv, (2024)
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The Journal of steroid biochemistry and molecular biology (2023): 106266-106266
Caroline A. Mcwhorter, Molly J. Mead, Megan D. Rodgers,Myla D. Ebeling,Judy R. Shary,Mathew J. Gregoski,Danforth A. Newton,John E. Baatz,Bruce W. Hollis,Martin Hewison,Carol L. Wagner
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2023): 106420-106420
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