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The primary research interest of the Blackledge group is the study of protein dynamics by NMR, often combined with complementary biophysical techniques and advanced molecular simulation, to characterize the role of conformational flexibility in biological function on a broad range of time and length scales, from molecular recognition dynamics in folded proteins, to reorganizational dynamics of large multi-domain assemblies exhibiting extensive protein disorder to the study of fundamental biophysics underlying protein dynamics. Most recently he uses these techniques to describe the conformational space sampled by highly flexible or intrinsically disordered proteins, to map their interaction trajectories at atomic resolution, and to determine the relationship between dynamic behaviour and functional mechanism. Amongst other applications these methods are applied to understand the function of highly dynamic proteins involved in viral replication, molecular signalling and neurodegenerative disease.
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crossref(2024)
Maiia Botova,Aldo R. Camacho-Zarco, Jacqueline Tognetti, Luiza Mamigonian Bessa, Serafima Guseva, Emmi Mikkola, Nicola Salvi,Damien Maurin, Torsten Herrmann,Martin Blackledge
biorxiv(2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Raghavendar R. Sanganna Gari,Grigory Tagiltsev,Ruth A. Pumroy,Yining Jiang,Martin Blackledge,Vera Y. Moiseenkova-Bell,Simon Scheuring
Communications biologyno. 1 (2023): 966-10
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Xiao-Han Li, Conny W. H. Yu, Natalia Gomez-Navarro, Viktoriya Stancheva,Hongni Zhu, Andal Murthy, Michael Wozny, Ketan Malhotra, Christopher M. Johnson,Martin Blackledge,Balaji Santhanam,Wei Liu,
PNAS NEXUSno. 1 (2023): pgae006-pgae006
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)
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bioRxiv : the preprint server for biology (2023)
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biorxiv(2023)
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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