Our research focuses on intermolecular interactions, in particular hydrogen bonds. An important goal is to study realistic model systems, such as small water, alcohol, amide or peptide clusters, by vibrational spectroscopy (infrared and Raman) in order to obtain benchmark data for their accurate quantum-chemical modelling. This is best done in the gas phase, where no complicating environmental influence exists. Supersonic jet expansions provide an excellent way of generating such model clusters. For example, we have studied stereoselective interactions between some of the simplest chiral molecules capable of hydrogen bonding, the smallest aggregates involving peptide bonds, or elementary proton transfer systems. Closer to the systems of interest in this graduate school, we have implemented infrared microscopy for the study of polymorphism, biological and polymer materials and other topics in which chemical imaging is useful.