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We are interested in the mechanisms that guide the assembly of neural circuits during development. We use the retinas as a model system, where we use two-photon imaging, electrophysiology and a variety of anatomical approaches to address two major questions. First, we study how immature retinal circuits generate retinal waves -- a term used to describe highly patterned spontaneous activity in the immature retina -- and what role this activity plays in the development of the retina and the retina's connections to the central visual system. Recently we have focused on a class of neurons called intrinsically photosensitive retinal ganglion cells as well as the role of waves in shaping glial cell morphology. In addition, we study the development and organization of the circuits that mediate direction selectivity in the retina.
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论文共 14 篇作者统计合作学者相似作者
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COLD SPRING HARBOR PERSPECTIVES IN BIOLOGYno. 2 (2024)
Cell reportsno. 2 (2022): 110225-110225
Trends in Neurosciencesno. 7 (2022): 529-538
The Journal of neuroscience : the official journal of the Society for Neuroscienceno. 20 (2022): 4101-4115
Neuronno. 5 (2018): 1059-1065.e4
Anna L. Vlasits,Ryan D. Morrie,Alexandra Tran-Van-Minh,Adam Bleckert, Christian F. Gainer, David A. DiGregorio,Marla B. Feller
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