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Since our initial proposal of the gene network hypothesis (1-3) our approach of studying Drosophila development has been linked intimately to evolutionary considerations. Thus, a central aspect of this hypothesis has been the postulate that both protein coding and cis-regulatory regions (enhancers) of genes consist of "domains" and that new genes and functions evolve by the independent assortment of domains (1). While earlier experiments tested predictions of the gene network hypothesis by concentrating on protein coding domains, later experiments analyzed the role of enhancers and emphasized their importance in the evolution of new functions (4).
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Developmental biologyno. 1 (2010): 106-123
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