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The brain is the most complex organ in the human body, containing over one hundred billion nerve cells. In contrast to other organs, the brain has a very limit capacity to regenerate and damage is often irreversible. One of the major ways the brain can become damaged is during inflammation. Inflammation is part of the process that the body uses to eliminate microbial infection but it also occurs during autoimmune disease and in response to external factors such as diet.
My research aims to understand the delicate balance of signalling factors that control inflammation in the brain and to explore the process of neurodegeneration. Part of my work focuses on how inflammation contributes to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. To do this, my laboratory uses both in vivo and in vitro models including cell culture, transgenic and knock-out mice, as well as experimental infection of mice with lymphocytic choriomeningitis virus (LCMV), a model for viral encephalitis.
In our lab, we offer research opportunities for undergraduate and postgraduate students. For more information, please visit www.hoferlab.com
The brain is the most complex organ in the human body, containing over one hundred billion nerve cells. In contrast to other organs, the brain has a very limit capacity to regenerate and damage is often irreversible. One of the major ways the brain can become damaged is during inflammation. Inflammation is part of the process that the body uses to eliminate microbial infection but it also occurs during autoimmune disease and in response to external factors such as diet.
My research aims to understand the delicate balance of signalling factors that control inflammation in the brain and to explore the process of neurodegeneration. Part of my work focuses on how inflammation contributes to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. To do this, my laboratory uses both in vivo and in vitro models including cell culture, transgenic and knock-out mice, as well as experimental infection of mice with lymphocytic choriomeningitis virus (LCMV), a model for viral encephalitis.
In our lab, we offer research opportunities for undergraduate and postgraduate students. For more information, please visit www.hoferlab.com
研究兴趣
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Alanna G Spiteri,Tamara Suprunenko, Erin Cutts, Andrew Suen,Thomas M Ashhurst, Barney Viengkhou,Nicholas J C King,Markus J Hofer
Virusesno. 3 (2024): 390
Barney Viengkhou, Christine Hong,Curt Mazur,Sagar Damle, Nicholas B Gallo,Terry C Fang, Kate Henry,Iain L Campbell,Fredrik Kamme,Markus J Hofer
The Journal of clinical investigationno. 4 (2024)
Cell reportsno. 6 (2023): 112559-112559
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JOURNAL OF NEUROCHEMISTRY (2023): 50-50
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
BRAIN BEHAVIOR AND IMMUNITY (2022): 91-105
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