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The complexity and heterogeneity of biological systems are formidable obstacles that must be overcome for achieving a more quantitative and predictive understanding of physiology and phenotypes on the cellular or organism scale. Such a level of understanding has remained largely elusive in biology, despite the extraordinary level of detail to which molecular interactions have been characterized over the past decades, as it often remains unclear how to harness detailed molecular knowledge to achieve this goal.
In our lab, we try to tackle these challenges by identifying phenotypic patterns that can guide us in decoding the underlying molecular mechanisms and principles, which govern the behavior of complex biological systems. Our approach relies on the close coordination and mutual feedback between experimental and theoretical efforts and we combine careful characterization of physiology, genetic perturbations, omics technology and theoretical models.
Fundamental biological questions that we are interested in include the role of metabolic strategies during growth and adaptation, tradeoffs between competing evolutionary objectives of microorganisms and how cells achieve homeostasis of cell size, cell number and cellular composition, as well as the breakdown of these mechanisms in disease. We use the well-characterized model organismsEscherichia coli and Drosophila melanogaster to address such questions.
In our lab, we try to tackle these challenges by identifying phenotypic patterns that can guide us in decoding the underlying molecular mechanisms and principles, which govern the behavior of complex biological systems. Our approach relies on the close coordination and mutual feedback between experimental and theoretical efforts and we combine careful characterization of physiology, genetic perturbations, omics technology and theoretical models.
Fundamental biological questions that we are interested in include the role of metabolic strategies during growth and adaptation, tradeoffs between competing evolutionary objectives of microorganisms and how cells achieve homeostasis of cell size, cell number and cellular composition, as well as the breakdown of these mechanisms in disease. We use the well-characterized model organismsEscherichia coli and Drosophila melanogaster to address such questions.
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论文共 48 篇作者统计合作学者相似作者
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Markus Basan,Avik Mukherjee,Yanqing Huang,Seungeun Oh,Carlos Sanchez,Yu-Fang Chang,Xili Liu,Gary Bradshaw, Nina Benites,Johan Paulsson,Marc Kirschner, Yongjin Sung,
Research square (2024)
Avik Mukherjee,Yanqing Huang,Seungeun Oh,Carlos Martínez Sánchez, Ying-Hsu Chang,Xili Liu,Gary A. Bradshaw, Nina Catherine Benites,Johan Paulsson,Marc W. Kirschner,Yongjin Sung,Jens Elgeti,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Dimitris Christodoulou,Avik Mukherjee,Rebekka Wegmann,A. Pagano, V. Sharma,Stephanie M. Linker, Ying-Hsu Chang,Julius Palme,Uwe Sauer,Markus Basan
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Avik Mukherjee,Yanqing Huang,Jens Elgeti,Seungeun Oh, Anjali Rebecca Neliat, Janik Schuttler, Nina Catherine Benites,Xili Liu,Mihail Barboiu,Hugo Stocker,Marc W. Kirschner,Markus Basan
bioRxiv : the preprint server for biology (2023)
bioRxiv : the preprint server for biology (2023)
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Shalaka Chitale,Wenxuan Wu,Avik Mukherjee,Herbert Lannon,Pooja Suresh, Ishan Nag, Christina M. Ambrosi,Rona S. Gertner, Hendrick Melo, Brendan Powers, Hollin Wilkins,Henry Hinton,
Nature Communicationsno. 1 (2023): 1-13
Shalaka Chitale,Wenxuan Wu,Avik Mukherjee,Herbert Lannon,Pooja Suresh, Ishan Nag, Christina Ambrosi,Rona S Gertner, Hendrick Melo, Brendon Powers, Hollin Wilkins,Henry Hinton,
bioRxiv : the preprint server for biology (2023)
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bioRxiv : the preprint server for biology (2023)
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