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They have also shown that in the sub-epithelial layer of the cornea early detection of nerve loss can be achieved by examining the region of the whorl. These results have translational importance for the early detection of obesity- and diabetic-induced peripheral neuropathy that could be used for examining the progression and repair of neuropathy in patients. In this regard they have been conducting studies in the use of menhaden oil (fish oil), a natural source for n-3 fatty acids, for the treatment of obesity- and diabetic-induced peripheral neuropathy. They have demonstrated that treating rodent models of pre-diabetes and types 1 and 2 diabetes with menhaden oil improves insulin resistance and vascular and neural complications. They have also shown that treating type 2 diabetic mice with resolvin D1 can improve diabetic peripheral neuropathy. They believe that the mechanism(s) responsible for the beneficial effects of menhaden oil is the reduction in inflammatory stress and production of resolvins and neuroprotectin, metabolites of n-3 fatty acids that have anti-inflammatory and neuroprotection properties. Studies are ongoing to investigate the mechanism(s) responsible for the beneficial effects of fish oils in obesity and diabetes. In addition clinical studies are being designed to test the benefits of fish oil treatment in subjects with diabetes.
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Heart rhythm (2024)
DIABETESno. Supplement_1 (2023)
Diabetesno. Supplement_1 (2023)
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Contemporary diabetespp.253-277, (2023)
DIABETESno. Supplement_1 (2023)
CURRENT DIABETES REVIEWSno. 5 (2022): 1-2
Journal of diabetic complications & therapyno. 1 (2022)
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