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Biomedical science has twin goals; to explain the many amazing properties of our own bodies and those of other animals, and to use this information to reveal the causes of disease and to suggest possible treatments. We work at the interface between cell and developmental biology, focusing on the epithelial tissues that form the basic architectural unit of our bodies and of those of other animals. We explore how the machinery mediating cell adhesion, cytoskeletal regulation and Wnt signaling regulates cell fate and tissue architecture in development and disease. Epithelial tissues like skin, lung, colon, and breast are affected in many cancers. Cancer results from alterations in normal cell behaviors. To explore underlying causes of epithelial tumors, we need to understand the basic cellular machinery that links cell adhesion, signal transduction and cytoskeletal regulation during normal development.
We focus on the machinery that modulates cell-cell adhesion and connects cell junctions to the actin cytoskeleton, thus shaping the architecture of epithelial tissues. We also explore the machinery that transduces and regulates Wnt signaling, which helps determine cell fates. Wnt signaling is inappropriately activated in colon and other cancers, while the cell adhesion machinery is inactivated in most metastatic tumors. We study these processes in the fruit fly Drosophila, combining classical and modern genetic tools with state-of-the-art cell biology, microscopy, and biochemistry, thus capitalizing on the speed of this model system and its synergy with vertebrate cell biology, and supplement this with work on cultured Drosophila cells and mammalian cells. Like all good science, our work sometimes leads us in unexpected directions–our recent wor on the roles of centrosomes in genome stability is an example.
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论文共 253 篇作者统计合作学者相似作者
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Corbin C Jensen,Mark Peifer
Proceedings of the National Academy of Sciences of the United States of Americano. 12 (2024): e2401735121-e2401735121
Mark Peifer, Alexander R Dunn
The Journal of cell biologyno. 4 (2024)
JOURNAL OF CELL BIOLOGYno. 4 (2024)
Journal of cell scienceno. 6 (2024)
bioRxiv : the preprint server for biology (2023)
Noah J. Gurley,Rachel A. Szymanski,Kia Perez-Vale, Kristi Yow, Amber Butcher, Emily McParland,Mark Peifer
MOLECULAR BIOLOGY OF THE CELLno. 2 (2023): 751-752
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