My lab studies individuals with epilepsy, focussing on one broad question: why do epileptic seizures start? In collaboration with mathematicians and engineers, we construct models of the human brain using a range of imaging and neurophysiological techniques, such as functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), electroencephalography (EEG), simultaneous EEG-fMRI and simultaneous transcranial magnetic stimulation (TMS)-EEG. We aim to understand the underlying mechanisms of seizure onset in terms of such models, comparing healthy people with people who have epilepsy. We also examine how antiepileptic drugs alter brain networks. In addition, we are investigating the long timescale mechanisms of epilepsy, through longterm monitoring of physiological parameters in people with epilepsy, using wearable and implantable sensors. We will use these data to understand why seizures occur at particular times and to forecast seizure onset in real-time.