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My primary research interest is estimating the effect of treatment from observational studies (i.e. looking at subjects who receive different treatments for clinical reasons, rather than from a randomised clinical trial). In a randomised trial, a given person is equally likely to receive either treatment. However, in an observational study, subjects with more active disease are more likely to receive treatment, and are also more likely to have a poor outcome. This can lead to the treatment correlating with poor outcomes, even if it does provide benefit to the patient. This is called "Confounding by indication" (confounding is when two variables are correlated not because one causes the other, but because they are both caused by a third variable).
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Rheumatology (Oxford, England)no. 4 (2024): 1093-1103
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Rheumatology (Oxford, England) (2023)
Rheumatology (Oxford, England) (2023)
BMJ openno. 3 (2023)
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