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The major goals of our research are the dissection of the mechanisms of cell and nuclear fusion during mating and the pathway of spindle pole body duplication. During mating, yeast cells respond to gradients of mating pheromone by growing toward one another in a polarized fashion. After adhering together, they remove their cell walls in the region of close contact and fuse their plasma membranes to produce a single cell. As cell fusion progresses, the two nuclei become connected by microtubules emanating from the organizing centers (spindle pole bodies). The nuclei then move together in a microtubule-motor-driven process. Subsequently, nuclear envelopes fuse in the vicinity of the spindle pole bodies, producing a single diploid nucleus. Accordingly, cell and nuclear fusion serve as powerful indicators of a variety of basic cell biological processes, including cell polarization, membrane fusion, nuclear movement, and microtubule organization. Using novel genetic screens, we have identified several genes required for cell and nuclear fusion. Using modern molecular genetic techniques, we are identifying and characterizing the proteins and their biological functions. A detailed analysis of the pathway of cell and nuclear fusion will be important for the understanding of a broad set of phenomena common to all eukaryotic cells. Descriptions of representative genes follow.
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biorxiv(2023)
bioRxiv : the preprint server for biologyno. 8 (2023): e1010896-e1010896
Geneticsno. 1 (2023)
bioRxiv : the preprint server for biology (2023)
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
Tim Arlow,Junwon Kim, Joanna E Haye-Bertolozzi,Cristina Balbás Martínez, Caitlin Fay,Emma Zorensky,Mark D Rose,Alison E Gammie
Research Notes of the American Astronomical Societyno. 1 (2018): 47
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