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Mark Pepys was born in Cape Town, South Africa and came to the UK in 1948. He was educated at Trinity College, Cambridge, where he was a Senior Scholar, and took a double first in the Natural Sciences Tripos. After qualifying in medicine at University College Hospital Medical School, he returned to Cambridge as a Research Scholar at Trinity for his PhD in immunology. He was elected to a Fellowship at Trinity in 1973 for his discovery of the role of complement in induction of antibody production. After training in clinical medicine and continued immunology research at the Royal Postgraduate Medical School he was appointed Head of the Department of Immunology at the Royal Free Hospital School of Medicine in 1976. In 1977 he returned to the Royal Postgraduate Medical School as Senior Lecturer/Consultant Physician and established the Immunological Medicine Unit, which became one of the world’s leading centres for basic and clinical research on the acute phase response and amyloidosis. He was appointed Professor of Immunological Medicine at the RPMS in 1984. In 1999 he was appointed Professor and Head of the Department of Medicine at the Royal Free Campus of University College London, and moved his whole Department there to establish the UCL Centre for Amyloidosis and Acute Phase Proteins. He also created the UK National Health Service National Amyloidosis Centre, funded by the UK Department of Health to provide diagnostic and management advisory services to the whole national caseload, and which also sees many patients from abroad. His research has been continuously supported by the Medical Research Council since 1969, including a Programme Grant from 1979 to 2009 followed by a Research Grant and the first award under the MRC Developmental Clinical Studies Scheme from 2010-2013 and a second DCS award from 2012-2015. He has also received generous support from the Wolfson Foundation and the Wellcome Trust, including one of the first Seeding Drug Discovery awards from 2007-2010. He is a Fellow of the Royal Society, a Founder Fellow of the Academy of Medical Sciences, and has been a member of the Councils of both academies. He was the Harveian Orator of the Royal College of Physicians for 2007 and winner of the Royal Society GlaxoSmithKline Prize in 2007. In 2008 he received the Ernst Chain Prize for medical discovery and in 2009 gave the Annual Keynote Lecture at the Academy of Medical Sciences. In 2011 he retired as Head of Medicine at the Royal Free Campus of UCL in order to become the first Director of the new UCL Wolfson Drug Discovery Unit, created with Wolfson Foundation support and core funding from the NIHR via the UCLH/UCL Biomedical Research Centre. He was created Knight Bachelor for Services to Biomedicine in the 2012 New Year Honours and was elected to an Honorary Fellowship of Trinity College, Cambridge in 2014.
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